Principal Research Associate, In Vivo Biology

Location
Seattle
Posted
Jan 20, 2021
Ref
5040729002
Required Education
Bachelors Degree
Position Type
Full time
Sana Biotechnology is seeking a creative and highly motivated individual to join the T-cell therapeutics team who will help bring gene and cell therapies to patients. This individual will be responsible for comprehensive execution of a research-stage in vivo program to test and advance T-cell based therapies. Experiments will be carried out in both xenograft and syngeneic murine models, using both cell and gene therapeutic candidates. In addition to animal manipulation and sample collection, this individual will process biological samples to assess therapeutic efficacy using a variety of techniques. Success in this role will require active collaboration with internal immunology team members as well as other members of the gene therapy, pharmacology, and process development teams.

DUTIES AND RESPONSIBILITIES
  • Comprehensive execution of in vivo experiments in multiple xenograft and syngeneic murine models to test efficacy of candidate T-cell therapeutics
  • Contribute to the design of experiments for in vivo testing of therapies in collaboration with team members and program leadership
  • Animal manipulation, sample collection, as well as processing and analysis of tissue samples using a variety of techniques including flow cytometry, qPCR, ddPCR, and other molecular and cell biology techniques
  • Staying up to date with current knowledge to enable onboarding and implementation of state-of-the-art innovative and novel animal models
  • Collaborate with pharmacology and toxicology teams to support IND-enabling studies
  • Function as an independent individual contributor while working closely with other members of the T-cell therapeutics, gene therapy, pharmacology, and process development teams to share and apply knowledge advancements
  • Provide mentorship to others through active engagement of junior team members and by presentation and discussion of scientific results
  • Reviewing and presenting data cross-functionally at department meetings and larger forums
  • Comply with standard laboratory practices and company policies, including notebook documentation and biosafety policies
  • Contribute to the overall Sana mission and culture

QUALIFICATIONS

Basic Qualifications
  • A BS or MS in a relevant discipline with a minimum of 5-7 years of relevant experience and proven proficiency in design and execution of in vivo experiments as well as sample assessment using a variety of laboratory techniques
  • Previous experience with xenograft and syngeneic murine cancer models, including animal handling as well as sample collection and processing
  • Familiarity and experience with CAR-T based therapeutic development and evaluation
  • Familiarity and experience with handling and delivery of viral vector-based products
  • Demonstrated expertise in novel animal model development and implementation, including the development and generation of humanized mouse models
  • Familiarity and proficiency with multiple routes of injection (i.m., i.p., i.v., etc.) and administration, tissue and blood collection techniques, as well as live-imaging techniques for monitoring of cell populations in vivo
  • Advanced experience with characterization and assay of immune cell populations using state-of-the-art techniques (e.g. Spectral flow cytometry)
  • AALAS certification is desirable
  • A strong self-starter, independent thinker, with a strong attention to detail
  • Experienced with interpersonal skills and an ability to adapt communication style to interact effectively with a range of collaborators including research associates, external technical experts, cell biologists, and therapeutic project teams
  • Excellent oral and written communication skills, attention to detail and data quality, and experience working on diverse collaborative teams
  • Ability to travel 10% of the time