Scientist - Bioinformatics

Graphite Bio is a clinical-stage biotechnology company focused on harnessing the power of targeted DNA integration. Integral Medicines uses next-generation CRISPR based technology platforms for developing curative gene correction-based stem cell therapies for serious and life-threatening genetic diseases with inadequate existing treatment options

Summary:

Graphite Bio is seeking a highly motivated Scientist, Bioinformatics, to develop the core bioinformatics pipelines to characterize CRISPR edits as well as DNA integration events in primary cells of therapeutic interest.

What You Will Do:

• Establish and optimize the bioinformatic pipeline for assessing on and off-target DNA edits using state-of-the-art next-generation sequencing methods.
• Develop informatic approaches to determine types and frequencies of DNA integrations as well as other on- and off-target double-stranded break meditated changes.
• Create NGS analysis workflows to characterize Drug Products derived using Graphite's gene-editing approaches for first-in-human clinical trials.
• Work with interdisciplinary teams including discovery research, preclinical pipeline development, and clinical science.

What You Will Bring:

• Ph.D. in computational biology, bioinformatics, genetics, or closely related field
• Experience developing and maintaining NGS analysis pipelines is a must
• Experience running analyses in different compute environments
• Use of R or Python for bioinformatic analyses of DNA variants
• Ability to clearly and succinctly communicate results
• Background working with engineered nuclease and/or CRISPR gene editing preferred
• In-depth knowledge of cell and gene therapy preferred
• Experience with single cell sequencing workflows a plus
• Strong publication record demonstrating significant contributions to the field
• Excellent communication, organization, interpersonal and scientific writing skills
• Proven ability to positively impact company culture and demonstrate flexibility in fast-paced environment

Fit with Graphite Bio's culture:

Ability to build strong relationships with co-workers of various backgrounds and expertise

Ability to function at a high level in a team setting whether leading the group or acting as an individual

contributor

Values-based leadership consistent with Graphite Bios' Core Values

Excitement about the vision and mission of Graphite Bio

Flexibility

Integrity

Compensation/ Benefits:

Competitive salary with equity

Free on-site gym access

Free on-site meals and coffee bar

Health benefits

Graphite Bio is an equal opportunity employer, and all qualified applicants will receive consideration for

employment without regard to age, race, color, religion, sex, sexual orientation, gender identity, national

origin, protected veteran status, or disability status, or any other characteristic protected by law.