Scientist I, Analytical Development

Location
Durham, NC, United States
Posted
Jan 16, 2021
Ref
1488794
Hotbed
Bio NC
Required Education
Bachelors Degree
Position Type
Full time
The Scientist I, CMC-Analytical Development Cell Biology, will perform as technical subject matter expert in the Cell Therapy bioassay/Immunoassay/Flow Cytometry group of Precision BioSciences. Within the CMC-Analytical Development department, this individual will coordinate development of highly novel methods, method optimization, and method execution and data analysis for the functional characterization of genome-edited cell therapy and gene therapy products. The incumbent will support efforts to develop analytical methods in support of cell therapy and gene therapy product in-process control and release. As a subject matter expert for cellular immunology and molecular biology, the Scientist I will interface with multiple stakeholders including Clinical Affairs, Technical Operations, Quality, and Regulatory to advance a pipeline of allogeneic CAR-T cell products from IND filing through to commercial launch.

Essential Duties and Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.

Primary responsibilities will include:

  • Develop, characterize, optimize and document analytical methods for the testing of genome-edited cell therapy and gene therapy products. Participate in transfer of assays to QC group, as appropriate
    • Multi-color Flow Cytometry
    • Immunoassay
    • Bioassay
    • Molecular assays (qPCR and dPCR)
  • Lead and coordinate multiple programs simultaneously with limited oversight from management
  • Mentor and train laboratory staff in the development and execution of cellular and molecular assays
  • Author, review and approve technical documents
  • Stay abreast of advances in the field of CAR-T cell therapy and gene therapy, including reviews of scientific literature and attendance at conferences


Qualifications
The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

Education/Experience

Required:
  • Masters degree (M.S/M.A.) in the biological sciences with 5+ years of related biopharma industrial experience and/or training, or equivalent combination of education and experience
  • Experience with molecular biology assays (qPCR and/or dPCR)
  • Experience in multi-parametric flow cytometry.
  • Experience with cellular assay development, including multiplex cytokine analysis and immunological functional assays
  • Experience with mammalian cell culture

Preferred:
  • Background in immunology
  • Ability to conduct research projects independently and analyze results
  • Strong communication skills, including written and verbal reporting to supervisor, team, multiple stakeholders across the company, and at conferences.


Travel Requirements
  • This position requires little to no travel.


Location
  • This is an office-based position located at the main headquarters in downtown Durham, NC.


Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS genome editing platform. This isnt just a statement supporting the products that were developing its a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com

Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.