Scientist, Protein Biochemistry

Location
Tarrytown, NY, United States
Posted
Jan 16, 2021
Ref
22908BR
Required Education
Associate Degree
Position Type
Full time
The Protein Biochemistry Group at Regeneron is seeking a biophysical chemist Scientist to provide analytical protein characterization through the use of ground-breaking technologies. You will be responsible for providing in-depth biophysical and biochemical characterization of proteins to support development programs in our pipeline. You will be expected to take on a role in applying a diverse array of sophisticated biophysical techniques to deepen our knowledge of labeled proteins and their heterogeneity to support regulatory submission. This is a permanent position in the Protein Biochemistry Group that will be responsible for development, purification and characterization of the critical protein reagents.

A Typical Day in this Role Might Look Like:
  • Purify and characterize labeled and unlabeled proteins and anti-drug antibodies at both small and large scale
  • Develop and implement new analytical techniques to assess the stability of labeled protein reagents including freeze/thaw studies; optimize labeling conditions and formulation buffers to improve reagent stability
  • Develop site-specific labeling methods as an orthogonal to amine coupling
  • Provide well characterized protein reagents to other departments in the company and to collaborators
  • Manage stability testing program for critical protein reagents
  • Manage and mentor research associates and work as part of a collaborative team to meet project milestones
  • Conduct experiments to determine quality attributes of labeled drugs that impact downstream assays
  • Maintain documentation of experimental procedures and results in a laboratory notebook per established guidelines
  • Provide timely support to internal and external collaborators and present results and reports at various meetings
  • This position will provide the opportunity to make visible contributions to a variety of projects while interacting with a knowledgeable and dedicated multidisciplinary team


This Job Might be For You If:
  • You have strong initiative and aim to complete challenging tasks and learn new technologies.
  • You are capable of multi-tasking, working both independently and within a team environment.

This role requires a PhD in Biochemistry, Bioengineering or related discipline with 0-2 years of experience with an emphasis on protein purification and characterization. Demonstrated solid proficiency in various protein purification techniques including affinity, ion exchange, gel filtration, HIC; strong FPLC/liquid chromatography experience. Experience with protein characterization techniques such as SDS-PAGE, Western blot, ELISA, Kinetic and Binding studies using SPR/BLI technology, CE-SDS, IEF/cIEF, SEC. Experience with additional analytical techniques, such as LC-MS, SEC-MALS, DLS, and DSC is a plus. Experience in labeling proteins with biotin, ruthenium, alexa fluor and other dye labels preferred. Ability to critically analyze and troubleshoot scientific problems. A high level of scientific initiative and ability to multi-task, prioritize work and handle multiple projects at once. Ability to work independently but also within a collaborative team environment and have flexibility to work on changing priorities. Excellent verbal and written communication skills.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.