Senior Scientist I/II, In Vivo Pharmacology

Cambridge, MA, United States
Jan 12, 2021
Required Education
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

AbbVie has invested in a new research enterprise in Cambridge, Massachusetts - the Cambridge Research Center (CRC). As part of CRC, the AbbVie Foundational Neuroscience Center (FNC) is investigating the fundamental biological mechanisms underpinning neurodegenerative diseases with particular attention to Alzheimer's disease (AD) and Parkinson's disease (PD).

We are seeking an experienced, hands-on Senior Scientist with 2-photon microscopy experience to join the In Vivo Pharmacology team at the FNC. This individual will be responsible for designing, executing and interpreting longitudinal in vivo 2-photon studies to support identification and preclinical validation of novel targets. Additional responsibilities will include designing and executing in vivo studies for target identification, target validation and preclinical efficacy in Alzheimer's disease and Parkinson's disease model systems to support drug discovery efforts. The candidate should have extensive laboratory research experience and a desire to continue in a laboratory-focused role. Strong communication and teamwork skills are essential as this individual is expected to operate in a fast-pace multi-disciplinary environment.

Key Responsibilities
  • Maintain a high level of productivity in the laboratory, and contribute technical and scientific expertise to the in vivo pharmacology team
  • Independently design, execute, and interpret critical experiments to answer scientific questions
  • Utilize expertise in 2 photon microscopy and in vivo pharmacology to support decision making on select targets
  • Work diligently and efficiently to meet deadlines in a fast-paced environment
  • Read and apply relevant scientific literature
  • Adhere to safety and compliance
  • Participate and present in internal meetings
  • Publish research in peer-reviewed journals and present work at scientific forums
  • Train and manage direct reports

  • PhD or MS or BA in Neuroscience, Biology or related field with 7-10+ years (BA), 5-8+ years (MS), or 0-4 years (PhD) of pharmaceutical, biotech industry, and/or academia experience
  • Expertise conducting longitudinal, in vivo 2-photon microscopy experiments in animal models of neurodegenerative disease
  • Must have excellent in vivo skills including stereotaxic surgery, dosing and tissue harvesting
  • Proficiency with ex vivo assay techniques (e.g. ELISAs, WB, qPCR) and/or histology/immunohistochemistry
  • Significant understanding of neurodegenerative diseases and mechanisms of neurodegeneration
  • Strong scientific writing skills, excellent verbal communication skills, and ability to work well in a collaborative team-oriented environment
  • Strong organizational skills that enable multitasking and working within timelines

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Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.