Scientist II, Fermentation

San Francisco, CA, United States
Jan 11, 2021
Biotech Bay
Required Education
Position Type
Full time
Position Overview

Nektar has an exciting opportunity for a Scientist II, Fermentation to join their team.

Performs upstream process research and development experiments within the Biologics group. Leads the Microbial Upstream Process Development group. Will develop higher performing microbial cell lines, adapt analytical methods for use with upstream samples and use bench-top bioreactors to characterize microbial cell lines in high cell density fermentation processes. This individual will author technology transfer documents and will also assist in the transfer of microbial fermentation processes onsite at commercial manufacturing facilities. Exercises technical discretion in the execution and interpretation of experiments that contribute to project strategies. Maintains familiarity with current scientific literature. Contributes to scientific literature and conferences. Uses professional concepts and company policies and procedures to solve a wide range of difficult problems in imaginative and practical ways. This position contributes to and supports the company's research and development efforts to create high value therapeutics to address unmet medical needs.


Manages the Microbial Upstream Process Development group, provides guidance to junior scientific staff, providing training as needed, and ensures adherence to company policies and quality requirements. Setup, operate and maintain bench-top bioreactors (2L to 10L) for microbial fermentation. Perform in process sampling and off-line metabolite and cell density measurements during fermentation runs. Adapt analytical techniques to assess product quality in fermentation samples, such techniques may include HPLC, SDS-PAGE, and ELISA. Execute shake flask screens to identify improved cell lines. Use design of experiment (DOE) approaches to identify superior process parameters. Communicate experimental plans and key results in presentations and technical reports. Works on complex problems in which analysis of data requires evaluation of various factors. Exercises judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions. Normally receives no instructions on routine work, general instructions on new assignments and may provide guidance to other lower level personnel. Participates in the development of patent applications. Interfaces with various departments, customers and partners. Uses professional concepts and scientific knowledge to contribute to the development of company concepts and principles to achieve objectives in creative and effective ways. Defines problems, develops approaches and develops experiments with sound judgment and some supervision. Puts work practices in context with larger team. Writes reports and protocols. May act as a principal investigator in conducting own experiments. May assist with implementing organizational systems, identifying capital equipment, and projecting near-term resource requirements.


A PhD in a scientific discipline is required. Equivalent experience may be accepted. A minimum of 4 years work experience in a research and/or development environment isrequired. Post-doctoral work may serve as experience. Exceptional non-PhDs with demonstrated capabilities and/or significant experience may also be considered. Must be able to demonstrate hands-on technical proficiency, scientific creativity, collaboration with others and independent thought. Microbial strain development experience is required. Additionally, mammalian cell experience is preferred but not required. Must be able to clearly communicate scientific information both written and oral with minimal assistance. Must be able to compose sound written work with minimal assistance. Must possess good oral and written communication skills. Must be able to demonstrate sound judgment and problem solving capabilities. Strong organizational skills are required. Good computer skills are required. Working knowledge of MS word, Excel, Power point is a plus. Experience working in an FDA regulated environment and knowledge of current GMPs as they apply to laboratory practices are a plus. Must be willing to work as part of a team and demonstrate good interpersonal skills.

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class. Nektar Therapeutics will consider for employment qualified applicants with criminal histories in the manner proscribed by the San Francisco Fair Chance Ordinance.