Senior Associate, Process Science

Biospace has partnered with our client, a therapeutics company that designs gene circuits and programs cells for tremendous therapeutic value to hire a Senior Associate to join our Process Development group for cell therapy programs. A successful applicant will have prior experience with process development and scale up of gene modified cell therapies and be comfortable in a fast moving and nimble culture.  Applicants should be familiar with culturing expanded allogeneic and autologous cell products, familiar with pre-clinical process development and GMP tech transfer to a CDMO, and adept at analytical methods and assays.
Responsibilities

• Contribute to process development for cell therapy development programs, including natural killer (NK cells), mesenchymal stromal cells (MSCs), CAR-T cells and other therapeutic cell modalities.
• Perform transductions on primary human cells via viral vectors and other gene delivery methods.
• Heavy process optimization efforts to increase process robustness, improve transduction efficiency, cell yield and purity.
• Independently perform experiments on process conditions and raw material qualification.
• Develop genetically modified cells under quality-controlled conditions suitable for transfer to a GMP facility.
• Collaborate with research teams on relevant product characterization assays (Flow Cytometry, ELISA , Luminex based assays and PCR)
• Help design and execute experiments with great attention to detail.
• Maintain accurate lab records and notebooks.
• Author protocols, reports and standard operating procedure documents.
• Present results in team meetings and deliver presentation to both small and large groups.

Qualifications

• Bachelor’s degree in Cell & Molecular Biology or related life science field.
• 3-4 years of process development experience, industry setting preferred.
• Prior experience drafting SOPs and working with Quality Systems.
• Experience with mammalian tissue culture including both adherent and suspension cells.
• Proficiency with flow cytometry strongly preferred.
• Ability to design and execute experiments with minimal technical supervision. 
• Ability to multitask and meet deadlines in a fast-paced environment.
• Highly organized and detailed oriented with strong troubleshooting and problem solving skills.
• Must be a team player, proactive and willing to work in a small team environment.
• Must have excellent verbal and written communication skills.
• Proficient with MS office and other commonly used software and technology platforms.
• Prism and Flowjo
• Self-motivated and eager to take on temporary responsibilities outside of initial job description.