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Senior Scientist / Principal Scientist, Computational Genomics & Data Science

Employer
Omega Therapeutics
Location
Cambridge, MA, United States
Start date
Jan 8, 2021

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Discipline
Information Technology, Business/Data Analytics, Science/R&D, Biotechnology, Genomics
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Genetown, NextGen Bio
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Job Details

About the Role:

Omega Therapeutics, Inc. is seeking a Senior Scientist or Principal Scientist, Computational Genomics & Data Science,with expertise in functional genomics algorithms and analysis, NGS methods development, and the ability to drive hypothesis-driven research by leveraging multidimensional omics datasets. The successful candidate will be an essential member of a close-knit team of computational and experimental biologists, a key contributor supporting drug development programs, and a lead in efforts to expand our core genomics-based target discovery platform. We are looking for enthusiastic, detail oriented and highly motivated individuals with a passion for bringing novel medicines to patients and who are comfortable working on a fast-paced scientific team.

Key Responsibilities:
  • Collaborate with bench scientists to identify key questions that can be addressed via genomics, partner in experiment design, and execute targeted computational analysis plans
  • Utilize advanced approaches for integrative analysis and visualization of multi-dimensional omics data to generate actionable hypotheses for individual therapeutic areas, and to advance the design of novel epigenomic controllers
  • Identify, evaluate, and apply new computational methodologies and emerging technologies in an opportunistic manner
  • Design innovative data pipelines and oversee HPC data footprint
  • Effectively communicate complex biological data to stakeholders at all levels in a manner elucidating key messages to speed decision-making

Required Skills:
  • Experience solving large-scale, real-world scientific problems within cross-functional, multi-disciplinary teams
  • Extensive experience with RNA-seq (bulk or single-cell) and functional NGS assays such as ChIP-seq, ATAC-seq, Cut&Run, WGBS, Hi-C, GRO-seq, etc
  • Understanding and experience with CRISPR-based technologies and computational analyses
  • Familiarity with modern statistical inference and biological modeling techniques, as well as systems biological and network analysis approaches
  • Fluency in R or python, linux HPC environments, and cloud computing
  • Prior understanding of epigenomics and gene regulation
  • Experience with genetics data, GWAS, eQTLs desirable
  • Strong presentation and excellent communication skills, both oral and written
  • Highly adaptable and responsive to technical and business opportunities - comfortable delivering against challenging project needs and timelines

Qualifications:
  • PhD. in Computer Science, Computational Biology, or related disciplines, with 3+ years of industry experience
  • Recognized excellence working in multidisciplinary teams as evidenced from peer-reviewed publications and strong references

Company

Omega Therapeutics is a publicly held, development-stage biotechnology company pioneering a new class of DNA-sequence-targeting, mRNA-encoded therapeutics to transform human medicine. The OMEGA Epigenomic Programming™ platform harnesses the power of epigenetics, the mechanism that systematically controls every aspect of an organism’s life from cell genesis, to growth and differentiation. The OMEGA platform has identified thousands of novel DNA-sequence-based epigenomic targets within Insulated Genomic Domains (IGDs), referred to as EpiZips™. IGDs represent the three-dimensional, distinct, and evolutionarily conserved architecture of the genome, and are the fundamental structural and functional units of gene control and cell differentiation. They act as the “control room” of biology. The OMEGA platform examines alterations in IGDs leading to aberrant gene expression, a cause of most disease. It then leverages its database of EpiZips to identify appropriate intervention points within the IGDs and rationally designs biologically engineered, modular, and programmable mRNA-encoded epigenetic medicines, called Omega Epigenomic Controllers™, to target EpiZips for Precision Genomic Control™. With its computation- and data-first approach, Omega Therapeutics is currently advancing a broad pipeline of programs that span regenerative medicine, multigenic diseases including immunology, oncology, and select monogenic diseases.

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Company info
Website
Phone
(617) 949-4359
Location
140 First Street
 Cambridge
MA
02141
United States
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