Senior Process Engineer, AAV Process Development
- Employer
- Intellia Therapeutics
- Location
- Cambridge, MA, United States
- Start date
- Jan 6, 2021
View more
- Discipline
- Engineering, Process Engineer, Manufacturing & Production, Process
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Genetown
Job Details
At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.
Job Description:
Intellia is seeking a skilled and motivated Senior Process Engineer to support AAV clinical scale process development and technical transfer in the Technical Operations organization. The ideal applicant will be experienced and capable in HEK suspension culture and transfection optimization for AAV production. The position requires development, optimization and scale up of AAV production in bioreactors as well as a good understanding of viral production analytics and purification technologies. Experience with documentation and technical transfer to GMP manufacturing is highly desirable. Team work, versatility, and strong problem solving/analytical skills are required.
Responsibilities:
- HEK293 stir tank bioreactor process development and transfection optimization.
- Develop and perform pre-clinical scale up production processes based on QbD.
- Develop SOPs, establish critical process parameters and lead technology transfers to CROs and strategic partners.
- Provide expertise and guidance in clinical AAV production, development and innovation across the organization.
- Communicate development results and production schedules with internal teams.
- Operate and maintain bioreactors and multiple laboratory instruments.
- Cell culture maintenance and analysis.
Qualifications:
- Bachelor's Degree in Biochemical Engineering, Molecular Biology, or Virology with at least 8 years of hands on industrial experience, or MS with 6+ years of industry experience.
- Experience with HEK suspension AAV production and characterization.
- Proficiency with operation and process optimization in stir tank bioreactors and relevant cell culture analytical techniques.
- Experience in bioreactor cell culture and purification process development scale up for GMP production.
- Experience with viral vector analysis is a plus (e.g. CE-SDS, ddPCR, ELISA).
- Effective inter-department coordination to meet project goals and timelines.
- Organized, detail-oriented, and a self-starter who continuously seeks innovative solutions.
- Excellent verbal and written communication skills.
#LI-KO1
EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Company
Many of us pursuing work in the biotechnology industry are inspired by a loved one who is living with a disease or the loss of someone in our community. Rare genetic and oncological and immunological diseases not only affect the people living with often debilitating and life-threatening symptoms, but these disorders also significantly impact their families, friends and caregivers.
Our researchers work tirelessly to harness the genome editing technology CRISPR/Cas9 for human therapeutic use. Jennifer Doudna, an Intellia co-founder, and Emmanuelle Charpentier were awarded the 2020 Nobel Prize in Chemistry for their pioneering work in CRISPR. We at Intellia are humbled to have a hand in making what we believe to be medical history. As a leader in this space, we take this responsibility to patients seriously.
We are employing a modular genome editing platform to create diverse in vivo and ex vivo pipelines, spanning a range of therapeutic indications. Guided by this full-spectrum approach, we are committed to making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to creating novel engineered cell therapies for various cancers and autoimmune diseases.
Change life stories with genome editing therapies!
Stock Symbol: NTLA
- Website
- http://intelliatx.com/
- Phone
- (857) 285-6200
- Location
-
40 Erie Street
Cambridge
Massachusetts
02139
United States
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