Senior Scientist - Downstream Process Development

Location
Redwood City, CA, United States
Posted
Jan 05, 2021
Ref
1787361369
Hotbed
NextGen Bio
Required Education
Bachelors Degree
Position Type
Full time

Kriya is a next-generation gene therapy company focused on designing and developing transformative new treatments for highly prevalent and severe chronic diseases. We target conditions where the underlying biology is well-understood, rationally designing one-time gene therapies to durably express therapeutic proteins within the appropriate human tissues.

Our lead programs are focused on the treatment of metabolic diseases such as diabetes (Type 1 and 2) and severe obesity. We are looking for a Downstream Process Development Scientist to join our team. This position requires a highly self-motivated and flexible individual who operates well in a start-up environment.

Essential Functions:
 

  • Initiates, directs and executes scientific research for innovation and process improvements independently
  • Establish a platform purification process for the generation of recombinant adeno-associated viral vectors (rAAV)
  • Critically analyzes complex data, interprets and integrates experimental results with project objectives
  • Independently perform experiments to maximize recovery and purity of AAV vectors from the upstream process
  • Employ state of the art purification strategies to maximize throughput
  • As a subject matter expert, maintain knowledge and implement state-of-the-art technologies and processes
  • Author documents in support of manufacturing activities
  • Manage activities, equipment, inventory and projects of the process development lab
  • Collaborate with other scientists and routinely present data
  • Coordinate tasks across multiple projects, demonstrating prioritization and planning. We are a start-up and are looking for applicants who are ready and willing to 'roll their sleeves up' and be the Key Driver to meet project timelines and milestones.
  • Perform other duties as necessary


Mandatory Education:

 

 

  • BS or equivalent with 10 years relevant experience, MS degree or equivalent with 8 years relevant experience, PhD or equivalent with 5 years relevant experience


Skills and Requirements:

 

 

 

 

  • Expertise in chromatography at all scales, and an in-depth knowledge of AKTA systems
  • Experience with Depth Filtration, Tangential Flow Filtration, and Sterile Filtration and scale-up techniques
  • Experience mentoring, coaching, and training junior staff members is preferred.
  • Excellent interpersonal skills, including clear, succinct, and timely communication and proven ability to foster strong relationships with other team members and stakeholders.
  • Highly self-motivated and detail-oriented, with proven ability to work in a dynamic, fast-moving team.
  • Comfortable working with a data-driven team
  • Experience with AAV purification desired
  • Knowledge of Ultracentrifugation