Research Associate/Sr. Research Associate, Protein Science

South San Francisco, CA
Jan 04, 2021
Required Education
Bachelors Degree
Position Type
Full time

Harpoon Therapeutics (ticker: HARP) is a clinical-stage immunotherapy company developing a novel class of T cell engagers that harness the power of the body’s immune system to treat patients suffering from cancer and other diseases. T cell engagers are engineered proteins that direct a patient’s own T cells to kill target cells that express specific proteins, or antigens, carried by the target cells. Using its proprietary Tri-specific T cell Activating Construct (TriTAC®) platform, Harpoon is developing a pipeline of novel TriTACs initially focused on the treatment of solid tumors and hematologic malignancies. HPN424 targets PSMA and is in a Phase 1/2a trial for metastatic castration-resistant prostate cancer. HPN536 targets mesothelin and is in a Phase 1/2a trial for cancers expressing mesothelin, initially focused on ovarian and pancreatic cancers. HPN217 targets BCMA and is in a Phase 1/2 trial for relapsed, refractory multiple myeloma. HPN328 targets DLL3 and is in a Phase 1/2 trial for cancers expressing DLL3, initially focused on small cell lung cancer and other tumors with high-grade neuroendocrine features. Harpoon is led by an experienced management team. The company emphasizes a collegial, collaborative environment and has a strong record of scientific innovation, pioneering protein engineering, expertise in tumor immunology and pre-clinical and clinical research. For additional information about Harpoon Therapeutics, please visit

We are seeking a highly motivated individual who enjoys detail-oriented technical work, can manage diverse responsibilities in the lab, and thrives in a fast-paced work environment. As an integral member of our functional group, this individual will work closely with other team members within Protein Science and partner with other functional areas including Biology, New Technologies, and Translational Medicine. The ideal candidate will have 1-5 years of experience in the purification of difficult proteins, operation and troubleshooting of AKTA Pure/AVANT, and performing standard lab biochemical techniques to validate the quality of purified proteins.


  • Execution of multi-step protein purification schemes using AKTA Unicorn-based methods
  • Chromatography sample preparation and protein formulation
  • SDS-PAGE, Spectrophotometry, Analytical SEC, and Western blot analysis of purified proteins
  • Protein chemistry, conjugation, and validation of reagent molecules for assays
  • Purification process development for Harpoon clinical candidates and transfer to CMC
  • Materials management and freezer inventory database maintenance
  • Maintain electronic lab notebook and databases, prepare reports, and make regular presentations to summarize results and update management


  • Training in Biochemistry, Biotechnology, Molecular Biology, or related fields
  • Bachelors + 1-5 years or Masters + 1-3 years of relevant experience in industry or academic lab
  • Experience in protein chemistry e.g. chromatography, labeling and conjugation, or analytics
  • AKTA Pure or Avant and/or Agilent HPLC experience a requirement
  • Experience in Downstream Process Development desirable
  • Demonstrated aptitude for detail-oriented work and following precise SOPs
  • Demonstrated aptitude for learning new techniques and handling diverse tasks concurrently
  • Ability to work independently on a project or with limited direct supervision
  • Fast learner with creative problem-solving ability