Senior/Principal Scientist, DNA Damage Response 高级/资深科学家

San Francisco, CA, United States
Jan 04, 2021
Biotech Bay
Required Education
Position Type
Full time
Position Purpose:

To lead biology efforts for projects in the area of DNA damage response. This team will play a critical role in target validation/the drug discovery and development process to ensure delivery of high-quality small molecule compounds with well-characterized mechanism of action.

Organizational Relationships:

Reports to the Head of Discovery Biology and Translational Medicine. This position requires extensive collaboration with Medicinal Chemistry, In vivo Pharmacology and DMPK

Resources Managed:

Oversight of direct reports and outsourcing activities

Primary Duties:
- Oversee activities in support of target validation/early drug discovery projects
- Contribute to define screening funnel for drug discovery projects
- Direct studies aimed at characterizing mechanism of action of lead small molecules
- Manage internal and external (academic and contract research organizations) resources to deliver quality data in an efficient manner
- Contribute to building a culture that embraces continuous learning and improvement, increasing technical skill base and disease biology expertise; take a proactive role in personal growth and scientific development

Qualifications & Prior Experience:
- PhD in Biochemistry or Cellular & Molecular Biology with an educational focus in cancer research and DNA damage response
- At least 3 years for Senior or 5 years for Principal Scientist role of experience in academia and/or pharmaceutical industry
- Strong understanding of key components and process of drug discovery
- Expert in biochemical assays, cell-based assays, RNAi and methodologies to support structure-activity relationship and target validation
- Demonstrated ability to work independently and supervise direct reports
- Strong communication skills and ability to work effectively in a multidisciplinary team environment
- Proven track record of productivity, as evidenced by driving projects forward and robust publications

Please send your resume to