Senior Scientist I/II, PBPK Modeler

Lake County, IL, United States
Jan 01, 2021
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

AbbVie is seeking a highly motivated scientist to join our DMPK and translational modeling team in North Chicago. The ideal candidate will have strong background and expertise in pharmacokinetics (PK) and ADME concepts and hands-on experience with PBPK modeling. In this exciting role, you will be expected to participate in implementing innovative and quantitative approaches to advance translational sciences. The position will involve conducting mechanistic PBPK, human PK, PBBM, and DDI projections to support Discovery and Development project teams, enabling compound progression from discovery to early stages of clinical development. You will also be expected to evaluate new technologies and approaches to support the mechanistic and translational understanding of drug disposition and drug-drug interactions. In addition, you will have opportunities to contribute to broader areas within DMPK by as your experience and expertise warrants.

Core responsibilities include:
  • Utilize PBPK and translational modeling tools to enable human PK projections
  • Evaluate and guide novel in vitro tools and methodology to improve prediction of human PK
  • Liaise with DMPK, discovery biology/pharmacology and clinical scientists to generate data and knowledge supporting the build-up of translational, mechanistic models
  • Communicate effectively and clearly both internally and externally on topics related to PBPK, translational modeling and simulation, human PK and DDI prediction
  • Keep up to date with emerging literature and science in modeling and in vitro approaches


Basic Qualifications:

  • Bachelors, Masters, or PhD with 0-4 (PhD), 8-10 (MS), or 10-12 (BS) years of experience in pharmaceutical or related field required.
  • Preferred degree in Pharmacology or Pharmaceutical Sciences.
  • Strong understanding of ADME, PK and DDI concepts.
  • Hands-on project experience in PBPK modeling and simulation through internship, industry research collaboration, or direct industry experience strongly preferred.
  • Thorough theoretical and practical understanding of own scientific discipline
  • Highly motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable to work both as team player and independent scientific contributor
  • Passion for data analysis, solving technical problems and applying new technologies to further scientific goals.
  • Hands-on experience in the use of commercial PBPK modeling software, especially SimCYP is preferred.

Key Leadership Competencies:
  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
  • Learns fast, grasps the "essence" and can change course quickly where indicated
  • Raises the bar and is never satisfied with the status quo
  • Creates a learning environment, open to suggestions and experimentation for improvement
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality

*Job level will be commensurate with experience

Significant Work Activities
Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Keyboard use (greater or equal to 50% of the workday)
Yes, 15 % of the Time
Job Type
Job Level Code
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.