AbbVie

Associate Scientist II, Histology

Employer
AbbVie
Location
Lake County, IL, United States
Posted
Dec 31, 2020
Ref
2008984
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Description:

AbbVie Oncology is currently offering a unique opportunity for a highly motivated histology associate to join our Translational Oncology -Pathology team focused on developing new therapies and translational IHC biomarkers for cancer treatment As an integral member of the multi-disciplinary Translational Oncology team, the individual will interface with internal and external biology, genomics/proteomics, in vivo and toxicology teams to investigate, identify, develop tissue-based biomarker assays including immunohistochemistry (IHC) and in-situ hybridization (ISH) biomarker assay development to support the AbbVie Oncology pipeline. Act as a lead scientist in his/her area of expertise and critically evaluate relevant scientific advances and integrate this knowledge into research or development programs to deliver novel clinical candidates.

Key Responsibilities:
  • Perform basic tissue grossing, processing, embedding (paraffin and OCT).
  • Perform routine histology, histology stains, and immunohistochemistry as well as follow established protocols.
  • Perform antibody optimizations for assay development
  • Generate tissue microarrays for target screening efforts
  • Maintain documentation for histology studies
  • Manage multiple tissue libraries and databases
  • Lead IHC assay development for chromogenic and/or multiplex fluorescence platforms
  • Explore and develop new technologies as needed, e.g. multiplex IHC, image analysis
  • Support target screening to identify biomarkers and indications for clinical development for multiple programs with internal and external collaborators, through lab-based activities.
  • Integrate complex data sets including DNA, RNA, protein evaluations (various platforms such as microarray, ISH, IHC etc) from preclinical models, procured tissue and patient samples from exploratory clinical trials to support target validation and biomarker development efforts.
  • Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug, GxP compliance and animal care where applicable.

Qualifications

Qualifications:
  • ASCP-HT certification preferred
  • BS degree in biology with 1-3 years histology experience or an Associate degree with 3-6 years histology experience.
  • Proficiency in paraffin and cryo sectioning.
  • Experience with multiple immunostainer platforms
  • Experience in digital imaging system (slide scanning and image analysis) preferred.
  • Experience in generation of tissue microarrays and/or in situ hybridization is a plus.
  • Industry experience is valued.
  • Organizational, record-keeping, and strong computer skills are essential.
  • Excellent interpersonal skills, able to work in a team-oriented environment.


Significant Work Activities
Keyboard use (greater or equal to 50% of the workday)
Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.