Manager/Sr. Manager Cell Therapy Logistics

Location
San Francisco, CA, United States
Posted
Dec 29, 2020
Ref
5011087002
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

Nurix, Inc. is seeking a Manager/Sr. Manager of Cell Therapy Logistics to join the Clinical Supply Chain team. This is a new role within the company. The incumbent will be instrumental in its creation. This individual will be responsible for all aspects of the planning and execution of logistics functions for Nurix's clinical Cell Therapy programs. This position reports to the Director, Clinical Supply Chain. The role requires the ability to manage multiple activities simultaneously, balancing priorities, ability to work with ambiguity, and significant attention to details.

This individual will be involved in work central to Nurix's strategic goals. They will apply existing technical skills, learn new skills, and play a role in development of the programs and help grow the company.

This position is primarily responsible for managing the critical, time sensitive aspects of Cell Therapy Logistics. Responsibilities include: working with Clinical Operations and Transport Vendors for shipping tumor samples to manufacturing sites from Clinical Sites, and return of Drug Product from manufacturing sites to Clinical Sites; coordination with CMC of the timing of manufacturing at production facilities; management of storage, and logistics vendors; inventory management of select Clinical Supplies at depots and sites; and, returns and destruction.
  • Participate in cross-functional team meetings internally and externally
  • Create and maintain a tracking process to ensure drug product traceability and chain of custody between clinical and manufacturing sites
  • Liaise with Clinical Operations/Sites to schedule pick up of Tumor Sample from Clinical/Manufacturing Sites
  • Liaise with Manufacturing/Vendors to ensure slot for Production of Cell Therapy Drug Product, and select Clinical Supplies
  • Collaborate with team members to resolve constraints or delays to mitigate potential risks
  • Collaboration with Quality Assurance to investigate exceptions in storage and logistics activities
  • Support the writing and revision of supply chain related Standard Operating Procedures
  • Participate in vendor selection
  • Accountable for process discrepancies
  • Facilitate technical troubleshooting when necessary, participate in investigations, and escalate as appropriate
  • Other duties as assigned


Required Qualifications
  • Bachelor's Degree or equivalent, preferably in a science, manufacturing, supply chain, operations management or business management background, with 5+ years of related work experience
  • Experience with Cell therapy and gene therapies highly preferred
  • Good understanding of current Good Manufacturing Practices (cGMP), Food and Drug Administration (FDA), and other regulatory requirements (EMA, TGA)
  • Perform tasks in a manner consistent with the safety policies, quality systems, and GMP requirements
  • Ability to influence others and work independently and in a team environment
  • Work experience in a supply chain, planning, or manufacturing role
  • Ability to effectively plan, prioritize, execute, follow up, and anticipate challenges
  • Experience managing complex schedules and priorities in dynamic environments
  • Ability to work, influence, and gain consensus across multiple functions (Manufacturing, Regulatory, Quality, and Clinical)
  • Ability to operate and thrive in a fast-paced, start-up environment
  • Analytical, problem solving and critical thinking skills
  • Expertise in the use of MS Excel, Office, and PowerPoint
  • Good Documentation Practices
  • Excellent interpersonal, verbal, and written communication skills
  • Self-motivated, builds trust easily and operates with integrity and ethics
  • Occasional travel


Bonus Qualifications
  • Experience in Global Cell Therapy Trials
  • Experience in Packaging & Labeling
  • Adept at developing visual management tools to provide status updates on organizational performance


Fit with Nurix Culture and Values
  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view


Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.