Principal Research Associate, Analytical Development

Location
Seattle
Posted
Dec 28, 2020
Ref
1751
Hotbed
BioForest
Required Education
Associate Degree
Position Type
Full time
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Sr. Research Associate/Principal Research Associate, Analytical Development

Good things are happening at Omeros!

Come join our Omeros CMC Team!

This position will support clinical development and commercialization of antibody therapeutics. The Sr. Research Associate/Principal Associate will bring a strong technical background including development, transfer, and qualification of analytical methods, characterizing physicochemical attributes of therapeutic candidates, developing new and orthogonal methods for extended characterization, and evaluating orthogonal and complimentary technologies to improve throughput. Experience with ELISAs and/ or Mass spectrometry is highly desired. This position will also contribute to tech transfer to clinical and commercial stage CRO's/CMO's.

Who is Omeros?

Omeros is a commercial-stage biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, complement-mediated diseases, disorders of the central nervous system and immune-related diseases, including cancers. In addition to its commercial product OMIDRIA (phenylephrine and ketorolac intraocular solution) 1%/0.3%, Omeros has multiple phase 3 and phase 2 clinical-stage development programs focused on complement-mediated disorders and substance abuse. Omeros also has a diverse group of preclinical programs including GPR174, a novel target in immuno-oncology that modulates a new cancer immunity axis recently discovered by Omeros. Small-molecule inhibitors of GPR174 are part of Omeros' proprietary G proteincoupled receptor (GPCR) platform through which it controls 54 new GPCR drug targets and their corresponding compounds. The company also exclusively possesses a novel antibody-generating platform.

What are your job responsibilities?

  • Analytical method development, testing, transfer, qualification, and validation in a GLP and/or GMP environment
  • Troubleshoot typical method and equipment challenges
  • Write standard test methods, technical reports summarizing analytical data, and qualification / validation reports
  • Participate in cross-functional teams as a representative of the Analytical Development group
  • Assists in trouble-shooting CMC-related problems from CROs / CMOs
  • Assists in investigations involving data generated internally and by CROs / CMO
  • Ensures laboratory equipment is calibrated and maintained in proper working order to enable compliance with GLP and/or GMP environments
  • Contribute to drafting regulatory submissions
  • Ensures compliance with all applicable regulatory guidelines
  • BS or MS degree in Chemistry, Biochemistry, Biology, Analytical Chemistry, or a related field with 7+ years of biotechnology and/or pharmaceutical industry experience.
  • Experience developing robust plate-based ELISA, Mass Spectrometric, HPLC (SEC, RP, peptide map, CEX, etc.) and/or CE-based (CE-SDS, cIEF, icIEF) methods
  • Experience with troubleshooting and optimizing methods
  • Experience with routine lab equipment and methods, including preparing buffers, measuring pH, UV absorbance, quantifying particulates, etc.
  • Strong understanding of technical principles of chromatographic and/or electrophoretic methods
  • Demonstrated problem solving and multi-tasking capabilities
  • Capable of interpreting data and communicating and presenting results to peers and management
  • Demonstrated written and verbal communication skills with peers and management
  • Demonstrated ability to build and maintain positive and collaborative relationships across functional areas and with management
  • Detail oriented, proactive, and self-motivated
  • Experience and proficiency with Waters Empower, Sciex 32 Karat, Agilent MassHunter software is highly desired
  • Experience with technology transfer to third parties is desired
  • Effectively manages team meetings and facilitates discussion and decisions
  • Must have the ability to build and maintain positive relationships with management, peers, and external clients
Physical Demands Required:
  • Intermittent physical activity including bending, reaching, pushing, pulling, or lifting up to 20 lbs.
  • May encounter prolonged periods of sitting or standing
  • This position requires working around hazardous materials located within the building
If you have the experience, skills and knowledge we are seeking, we'd love to hear from you! This is an exciting opportunity for the right person!

Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to hr@omeros.com or contact Omeros, asking for Human Resources, at (206) 676-5000