Scientist I or II, Cell Therapy Discovery

Location
Durham, NC, United States
Posted
Dec 24, 2020
Ref
1471991
Hotbed
Bio NC
Required Education
Doctorate/PHD/MD
Position Type
Full time
The Scientist I or II works within the Cell Therapy Discovery Team to advance Precisions approach to engineering T cells and producing cell therapy products with applications in immuno-oncology. The Scientist carries out research projects that support development of T cell therapy platforms in accordance with Precisions goals. The Scientist I/II position is lab-based and will share facilities and resources within the Cell Therapy Discovery team.

Essential Duties and Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.
  • Provide leadership in advancing chimeric antigen receptor (CAR) internal research and development programs and external collaborations from construct design and cell production through functional analyses
    • Coordinate with Cell Therapy Associate Director and senior team members to plan and execute experiments to achieve Precisions goals for developing T Cell Therapies
      • Generation and characterization of CAR T and/or recombinant TCR T cells
      • Plan and perform cell based assays to evaluate new CAR and TCR constructs, and other novel gene-edits in engineered T cells, including in vitro analyses of proliferation, cytotoxic activity, and cytokine release
      • Coordinate in vivo experiments in appropriate murine models to evaluate efficacy and safety of gene-edited T cells
    • Coordinate with other scientists, research assistants and research associates to plan and execute collaborative experiments supporting Cell Therapy research projects
    • Contribute to driving the scientific direction of the Cell Therapy group by attending conferences, studying related literature, and incorporating new concepts into experimental design
    • Report results to Cell Therapy team, upper management, external parties
      • Share new data, file reports as needed, maintain updated electronic lab notebook records
      • Assist in publishing, patenting or presenting data as needed
  • Assist in general operation of the Cell Culture facility
    • Coordinate with Cell Therapy Team to make sure:
      • SOPs are written and updated for techniques and assays
      • Equipment is properly maintained
      • CO2 and LN2 tanks are filled when needed
      • Shared resources are utilized appropriately between teams
      • Consumables are ordered and stocked as needed
      • Cells and other reagents are available for experiments as needed


Qualifications

The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

Education/Experience:

Required:
  • PhD in cellular & molecular biology/immunology or equivalent combination of education and experience. PhD with a minimum of 2 years related academic or industry experience and/or training preferred.
  • Demonstrated expertise in primary T cell culture, with preference given to candidates with in-depth knowledge and experience with cell-based assays of lymphocyte function, including proliferation, cytotoxicity, and cytokine release assays
  • Experience with multiparameter flow cytometric analysis and accompanying data analysis software proficiency

Preferred:
  • PhD with a minimum of 2 years related academic or industry experience and/or training
  • Experience and knowledge of molecular biology techniques, including: PCR, restriction digestion & cloning, primer design, plasmid isolation and analysis, bacterial transformation and screening, extraction of genomic DNA, DNA sequencing and analysis, and proficiency with accompanying data analysis software
  • Familiarity and experience with siRNA, shRNA, protein engineering, and gene editing
  • Ability prepare and present scientific concepts and data at in-person and virtual meetings
  • Ability to read, analyze, and interpret common scientific journals. Ability to define problems, collect and analyze data, establish facts, and draw valid conclusions. Should have knowledge of Microsoft Office software suite
  • Ability to respond to common inquiries or complaints from customers, regulatory agencies, or

members of the business community
  • Ability to apply advanced mathematical concepts such as exponents, logarithms, quadratic

equations, and permutations
  • Ability to apply mathematical operations to such tasks as frequency distribution, determination

of test reliability and validity, analysis

Travel Requirements
  • This position requires little to no travel (5%)


Location
  • This position is located at the main headquarters located in Durham, NC and is required to physically be and work in the office, in order to be most effective, and at managers discretion.


Precision BioSciences, Inc. is dedicated to improving life by developing advanced tools to edit DNA with a uniquely specific approach. Our proprietary method relies on a single small enzyme, ARC Nuclease, which combines cutting with sequence recognition and can be redesigned to find and edit new target sites across the genome. This simple, powerful gene editing solution allows us to create products that solve not just treat, but solve significant problems in oncology, genetic disease, agriculture, and beyond. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented, committed people who are excited to be a part of the medical and scientific breakthroughs enabled by Precisions next generation gene editing technology. For additional information, please visit www. precisionbiosciences.com

Precision BioSciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.