Senior Scientist II/Principal Scientist I, Parkinson's Disease

Cambridge, MA, United States
Dec 22, 2020
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Job Description

AbbVie is investing heavily in a new research enterprise in Cambridge, MA - the Foundational Neuroscience Center (FNC). The FNC is investigating the fundamental biological mechanisms underpinning neurodegenerative diseases, initially Alzheimer's disease. We are now growing our research remit to take advantage of shared disease mechanisms, building a new research team focused on Parkinson's disease (PD) to discover and develop disease-modifying therapeutics for this devastating disease!

We are seeking a highly motivated Principal Research Scientist with extensive expertise in Parkinson's disease and a strong background in lysosomal biology to join the Parkinson's Biology Area team! As a key, senior member of our team, you will drive actively the target identification and design in vitro and in vivo models of PD and use them to validate novel drug discovery targets, and to identify and characterize drug leads and candidates.

Key Responsibilities Include
  • Actively drive the selection and discovery of novel targets for Parkinson's disease
  • Establish strong scientific and technical initiatives and hands-on implementation for new target discovery in lysosomal biology
  • Advance science from the bench by crafting and executing in vitro experiments to validate novel targets using relevant cell lines, primary neurons and/or iPSC-derived neurons
  • Build and execute biochemical and cell-based assays to support novel target validation
  • Execute projects through experimental designs, critical analysis and interpretation of results and communication of results promptly
  • Collaborate with cellular and molecular biologists, in vivo pharmacologists, geneticists and medicinal chemists across global research sites
  • Present research at internal and external meetings, and publish in peer-reviewed journals
  • May supervise one or more direct reports and proactively engage in their development

  • Bachelors, Masters, or PhD in Neuroscience or closely related field with typically 12-14+ (BS), 10-12+ (MS) or 4-6+ (PhD) years of experience; Pharmaceutical industry experience preferred
  • Former experience in Parkinson's disease biology and/or drug discovery preferred
  • Proficiency with standard cell and molecular biology, biochemistry, enzymology and neuroscience techniques including gene transfer methods, microscopy and high-content imaging, protein detection & quantification (such as ELISA, MSD, plate readers), and enzyme kinetic assays
  • Expertise with culturing primary neurons and iPSC-derived neurons and their genetic or pharmacological manipulation
  • Extensive bench research experience and enjoy a central role in a fast-paced, multidisciplinary environment
  • Ability to design, execute and interpret experiments independently, and to advance scientific understanding
  • Excellent written and verbal communication; Strong interpersonal and teamwork skills
  • Strong organizational skills that enable multitasking and working within timelines

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Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.