Scientist, Biomarkers

Emeryville, CA, United States
Dec 22, 2020
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
4D Molecular Therapeutics (4DMT) is a gene therapy company with a transformative discovery platform— Therapeutic Vector Evolution —that enables our “disease first” approach to product discovery and development, thereby allowing us to customize our AAV vectors to target specific tissue types associated with the underlying disease.

4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers uniquely generous benefits, and provides challenging opportunities for career development. Join us in creating the ultimate gene therapy products to cure genetic diseases in children and adults. 4D Molecular Therapeutics, located in Emeryville, CA.


4D is in need of a talented and motivated scientist and Biomarker specialist to join a growing group of scientists developing assays for pre-clinical pharmacology and toxicology studies and clinical trials. The role will involve considerable cross-functional interactions with our vector discovery and payload engineering groups, translational, clinical medicine and our manufacturing group.

  • Develop and design cutting edge, innovative bioassays for preclinical and clinical use in multiple therapeutics areas, e.g. neuromuscular and lung, through expertise, and scientific teamwork
  • General areas of biomarker development will be in genomic and gene expression, immunologic, protein and histologic and cell-based assays
  • Designing, executing, and analyzing data using next-gen analytical techniques
  • Contributing to the design, implementation, and interpretation of the results of in vivo and in vitro experimental studies
  • Assessing the utility and selection of contract research organizations (CROs), technology transfer, overseeing assay method development, qualification and validation
  • Performing hands-on research in the company's lab to develop in house bioassays
  • Potential for contribution to analytical development bioassays
  • Leveraging a strong understanding of bioassays, assess and interpret experimental data, then using the resulting information to inform the further product development
  • Effectively mentoring junior level staff and acting as a resource for scientific expertise
  • Utilizing appropriate scientific approaches to understand characteristics of gene expression and protein function to drive decisions and assess potential application of company's lead adeno-associated virus vectors and products
  • Maintaining current awareness of scientific literature
  • Actively applying new concepts and technologies
  • Leading and supporting research initiatives such as new technology development and platform improvement projects
  • Writing study reports and manuscripts and presenting results at scientific meetings
  • Maintaining compliance with company Environmental Health and Safety policies, procedures, and practices
  • Contributing to building a culture that embraces continuous learning, improvement, and innovation and encourages team members to expand their technical skill base and deepen their gene therapy expertise.

  • Education:
  • Bachelors in Bioengineering, Molecular Biology, Cell Biology, Biochemistry or related field

  • Experience:
  • With a PhD - 4+ years of industry experience (Masters with 6+, Bachelors with 8+ Years), biomarker/bioassay development strongly preferred
  • Experience in one of the following disciplines: Bioengineering, Molecular Biology, Cell Biology, Biochemistry, or a related field

  • Skills:
  • Successful demonstrated ability to work independently in designing and developing novel gene regulatory elements and engineered protein variants.
  • Successful demonstrated ability to work independently in designing, developing, and executing new assay methods
  • Successful demonstrated ability to conduct research with strong attention to detail and rigorously analyze and interpret data
  • Ability to multi-task and support more than one project simultaneously
  • Highly organized and motivated; strong analytical, organizational, and problem-solving skills
  • Strong work ethic, flexibility, and cooperative can-do attitude
  • Ability to work cooperatively in a team-based environment; supportive of multiple viewpoints and approaches
  • Strong communication skills (both written and oral) with demonstrated ability to present ideas, information and data effectively via one on one discussions, team meetings, and external partnership interactions
  • Understanding and knowledge of key scientific software programs (including Microsoft Office, JMP or Prism, Adobe Photoshop, and bioinformatics and protein structure applications such as Swiss-Pdb Viewer).

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities