Research Associate III, Non-Clinical PK

Location
San Francisco, CA, United States
Posted
Dec 22, 2020
Ref
5267-363-R
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Position Overview

Nektar has an exciting opportunity for a Research Associate III to join their Non-Clinical PK Team.

The Non-Clinical PK department within Nektar Therapeutics is seeking to hire a highly motivated and experienced Research Associate III. Will be responsible for large molecule bioanalysis including biomarkers in support of our immuno-oncology and immunology programs. The successful candidate will develop immunoassay/ligand binding assays (LBAs) and other bioassays or cell-based assays for the quantification of large molecule drug candidates, biomarkers, and anti-drug antibodies in biological matrices to support preclinical PK/PD/TK studies. S/he will apply the technical expertise in the design, execution and interpretation of experiments that contribute to project strategies. This position contributes to and supports the company's research and development efforts to create high value therapeutics to address unmet medical needs
  • Develop robust immunoassays/ligand binding assays and other bioassays or cell-based assays for the quantification of large molecule drug candidates, biomarkers, and anti-drug antibodies in biological matrices
  • Conduct bioanalytical sample analysis for non-GLP PK/PD/TK studies
  • Analyze, interpret, summarize and present large molecule DMPK/BA data to internal project teams
  • Write, edit, and finalize DMPK/BA technical reports supporting regulatory filings
  • Stay current with the latest bioanalytical methods and technologies; identify, evaluate and implement the new technologies as needed
  • Serve as a liaison between Non-clinical PK and the translational group as well the regulated BA group for method transfer
  • Maintains accurate and well-organized laboratory records, worksheets, and notebooks
  • Compliant to company Environmental Health and Safety policies, procedures, and practices
A minimum of a Bachelor's degree in a scientific discipline (biochemistry / cell biology / immunology) is required. Equivalent experience may be accepted. A minimum of 5 years work experience in a research and/or development environment is required. Must have hands-on experience in immunoassay/ligand binding assay development, execution and troubleshooting, and conduct of large molecule bioanalysis and quantification in biological matrices. Strong background on immunoassay technologies, such as ELISA (direct and indirect sandwitch formats), Luminescence, Colorimetric, Electrochemiluminescence (MSD), etc to support preclinical PK/PD/TK studies. Knowledge and experience with mass spectrometric analysis and quantification of proteins is a plus. Experience with developing automated sample handling and assay processes is desirable. Knowledge of GLP, GCP, Bioanalytical and immunogenicity guidance (FDA/EMA) is a plus. A working knowledge of large molecule pharmacokinetics and protein biochemistry and characterization would be beneficial. Must possess good oral, presentation, and written communication skills. Good computer skills are required. Working knowledge of MS word, Excel and Power point. Must be willing to work as part of a team. Must be able to demonstrate good interpersonal skills. Other traits: Self-motivated, fast paced environment, able to find alternative solutions.

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class. Nektar Therapeutics will consider for employment qualified applicants with criminal histories in the manner proscribed by the San Francisco Fair Chance Ordinance.