Senior Director, Cell Line Development

Location
Oceanside, CA, United States
Posted
Dec 21, 2020
Ref
2082986
Required Education
Doctorate/PHD/MD
Position Type
Full time
Senior Director, Cell Line Development
United States - California - Oceanside

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company’s five core values. That’s because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible


Gilead Sciences, Inc. is a research-based biopharmaceutical company founded in 1987. Together we deliver life-saving therapies to patients in need. With the commitment and drive you bring to the workplace every day, you will be part of a team that is changing the world and helping millions of people live healthier, more fulfilling lives. Our worldwide staff is a close community where you can see the tangible results of your contributions, where every individual matters, and everyone has a chance to enhance their skills through ongoing development. Our scientific focus has resulted in marketed products that are benefiting hundreds of thousands of people, a pipeline of late-stage drug candidates, and unmatched patient access programs to ensure medications are available to those who could otherwise not afford them. By joining Gilead, you will further our mission to address unmet medical needs and improve life by advancing the care of patients with life-threatening diseases.

Gilead has an opportunity for a highly motivated team leader in our Biologics Development group at our Oceanside facility in Southern California. We are seeking a leader with significant experience leading Cell Line Development teams for generating mammalian cell lines producing monoclonal antibodies and recombinant proteins. This leader will work in a collaborative, high-performing, fast-paced environment to develop cell lines for Gilead's biologics pipeline projects.

The Pharmaceutical Development and Manufacturing organization has a diverse workforce in 11 countries. PDM is responsible for all development and manufacturing activities encompassing process and device development, production, analytical operations, information systems, quality assurance and regulatory affairs, as well as supply chain management for all of Gilead's small molecules, biologics and antibody-drug conjugates in development programs and commercial products. You will see the tangible results of your contributions, where every individual matters, and everyone has a chance to enhance their skills through on-going development. Our scientific focus has resulted in marketed products that are benefiting hundreds of thousands of people, a pipeline of late-stage drug candidates, and unmatched patient access programs to ensure medications are available to those who could otherwise not afford them. By joining PDM at Gilead, you will further our mission to address unmet medical needs and improve life by advancing the care of patients with life-threatening diseases.

Key Responsibilities:

  • Lead team of scientists to conduct cell line development for monoclonal antibodies and recombinant proteins.

  • Lead end-to-end Cell Line Development for pipeline projects, including activities from vector design and construction to clonal cell lines ready for Master Cell Bank generation.

  • Drive process improvements for increased speed and efficiency in order to generate highly productive, high quality, robust cell lines that meet all regulatory requirements with high quality documentation.

  • Develop and motivate team, and develop careers of direct and indirect reports.

    Qualifications/Skills/Experience:
    • 14+ years of industry experience with a PhD degree in chemical engineering or related discipline is required. Candidates with BS or MS degree may be considered with Biologics and Cell Line Development experience.
    • Demonstrated excellence and experience in cell line development is required, including:
    • Experience in mammalian gene expression systems and productivity enhancing technologies
    • Experience with automation and high-throughput technologies as applied to mammalian cell line generation and process optimization
    • Experience in a range of cell line selection and screening methodologies
    • Experience with controlling product quality by cell engineering and/or cell line selection
    • Demonstrated ability to work in a highly collaborative environment and adhere to timelines
    • Ability to think critically, and demonstrated troubleshooting and problem-solving skills
    • Excellent interpersonal, communication and presentation skills are required
    • Flexibility and a willingness to expand skill set and responsibilities is a must
    • Experience with the preparation of regulatory submissions is required
    • Experience and knowledge in GMP cell banking operations is preferred



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