Director, Oncology Biology- Transcriptional Regulation

Director, Oncology Biology- Transcriptional Regulation
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company’s five core values. That’s because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible


Position Purpose:

Contribute to the goal of discovering novel therapeutics targeting inherent or acquired mechanisms of immunotherapy resistance. Design and implement a strategy to comprehensively validate cancer drug targets, and direct biology efforts for transcriptional regulation and signal transduction projects.

Organizational Relationships :

Reports to VP of Oncology Biology, and closely collaborates with the Medicinal Chemistry team, Core Teams, and scientists across the company.

Resources Managed:

Leads a team of PhD and non-PhD biologists (4-6) focused on transcriptional regulatory mechanisms of immunotherapy resistance as well as signal transduction; manages/directs relevant external collaborations.

Primary Duties :

Lead a team of scientists dedicated to Cancer Biology, Target Validation and Drug Discovery using in vitro and in vivo methodologies

Contribute to the Oncology Biology strategy and participate in the nomination of new potential transcriptional and signaling targets

Direct genetic and pharmacologic strategies to identify and validate novel targets

Partner with Medicinal Chemistry and relevant partner groups to drive the discovery of novel compounds/antibodies with therapeutic potential

Identify, develop, and manage external collaborations with world class experts to advance our competitive advantage in improved target validation and drug discovery

Ensure scientific rigor across team and focus resources towards delivery of company goals

Contribute to building a culture that embraces continuous learning, improvement and innovation, and strives to increase technical skill base and disease biology expertise; take a proactive role in personal growth and scientific development

Mentor staff scientists

Qualifications & Prior Experience :

PhD plus post-doctoral training in Cell Biology, Molecular Biology, Biochemistry (or a comparable biological science) with a cancer-related focus

Min 8+ years of experience in industry or in an applied academic lab focused on target validation and drug discovery

• Deep and broad knowledge of targets and pathways of importance to cancer biology with 12 years of experience working primarily on cancer biology

• Experience driving projects in the area of transcriptional regulation including epigenetic targets, co-regulatory targets, nuclear hormone receptors, etc, as well as in the area of cell signaling.

Expert in advanced in vitro and in vivo models; good understanding of relevant methodologies for target validation (RNAi, CRISPR, etc)

Demonstrated ability to identify, develop, and manage successful external collaborations

Ability to build strong collaborative relationships and effectively manage scientific teams

Excellent communication skills

Demonstrated success in designing and implementing strategy

Track record of innovation - designing and delivering novel solutions to challenging problems

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