Senior Scientist, CAR-T Immuno-oncology

Location
Cambridge, MA, United States
Posted
Dec 16, 2020
Ref
L383
Hotbed
Genetown
Required Education
Masters Degree/MBA
Position Type
Full time
Our Mission: Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Job Description:

Intellia Therapeutics, a CRISPR/Cas9 company, is seeking a CAR-T cell scientist to lead the functional characterization of our allogeneic CAR-T cell products. This talented and highly motivated Senior Scientist will join our Immuno-oncology group. In this lab-based role you will develop and functionally characterize CAR-T cell drug products for our ex vivo portfolio. Prior IO cell therapy experience is highly desired as you will lead key aspects of in vitro and in vivo CAR-T development at Intellia. The successful candidate will be comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities. Intellia is a cross-functional team first organization, as such experience working well in teams in an industry setting is key.

Responsibilities:
  • CAR T cell generation, functional assessment and immunophenotyping
  • Coordinate and collaborate with colleagues to execute in vivo studies to assess CAR-T cell anti-tumor efficacy and safety using mouse models
  • Work collaboratively with other biologists and protein engineers
  • Creative thinking to propose and implement innovative cell engineering approaches to expand company's preclinical pipeline and intellectual property
  • Maintain detailed records of experimental protocols and results
  • Stay up to date on the latest scientific and technology advancements in the field

Qualifications:
  • MS or PhD in Immunology, Cell Biology, or related field with typically 8+ (MS), or 5+ (PhD) years of relevant experience
  • Strong expertise in human T cell biology and in vitro functional assays utilizing human primary T cells; experience with CAR T, TCR-T, or a related cell therapy platform to target hematologic and/or solid tumors is required
  • Hands-on experience with in vitro and ex vivo phenotypic and functional assays of primary human immune cells, including multicolor flow cytometry, cytotoxicity / cytokine assays, MLR, and cell tracking in vivo is highly desired
  • Hands-on proficiency in primary immune cell isolation and culture
  • Experience working with cell-line derived, PDX, or GEM murine tumor models


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EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.