Associate Scientist, T-cell Process Development

Cambridge, MA, United States
Dec 16, 2020
Required Education
Bachelors Degree
Position Type
Full time
Our Mission: Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Job Description:

Intellia is seeking a motivated Associate Scientist to join our T-cell Process Development team, supporting ex vivo programs. The primary responsibilities for this position include process unit optimization and scaling of procedures for editing T-cells using CRISPR/Cas9, across multiple programs. In addition, the role will involve participation in process tech transfer to an external CMO, including MBR/SOP review and training. The ideal candidate will be familiar with cell-mediated immunity, T-cell receptor diversity, and assays to study T-cell related oncology tools.

  • Contribute to the design, development, and optimization of a functionally closed-system process for the manufacture of genetically modified T cells for the treatment of cancer
  • Design and execute complex small-scale and full-scale experiments involving the isolation, expansion and cryopreservation of primary T cells
  • Optimize gene editing in primary T cells using the CRISPR Cas9 system
  • Utilize an array of analytical techniques (FACS, ELISA, qPCR, cytotoxicity) to understand the dynamics and behavior of genetically modified T cells
  • Contribute to cell-based assay development by designing experiments, screening reagents, and troubleshooting critical parameters
  • Interact cross functionally in order to effectively support early-stage development of product candidates
  • Write SOPs, technical reports, and maintain a highly detailed electronic lab notebook
  • Present data across multiple teams
  • Stay informed of recent advances in the field of cell therapy by reading scientific journals and attending conferences

  • Bachelor's degree in Biochemistry, Biology, Biological Engineering, or Immunology with 5+ years of hands-on experience or Master's degree with 2+ years.
  • Previous hands-on experience with large scale closed system cell processing equipment such as CliniMACS, Sepax, Rotea, Prodigy, and Xuri bioreactors is highly desirable. Experience with clinical scale cell therapy manufacturing equipment preferred.
  • Process flow design, SOP drafting and review, and development report drafting, required.
  • Demonstration of aseptic cell culture techniques, including cell banking and expansion.
  • Ability to work effectively with management, process and analytical development, and supply chain to aid in sourcing reagents; and evaluating multiple vendors to inform process decisions.
  • Thorough knowledge of immunology with a focus on T-cell function and differentiation is required.
  • Previous experience in flow cytometry, including data analysis in FlowJo and cytometer operation preferred.
  • Familiarity with gene editing techniques, including electroporation and transduction.
  • Self-motivated with a passion for bringing life changing therapies to patients.
  • Willingness to acquire new skills and ability to work with minimal supervision.
  • Ability to communicate effectively with strong writing skills, and thrive in a team with time critical objectives.


EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.