Intern- Analytical Operations, Core Team

Location
Foster City, CA, United States
Posted
Dec 15, 2020
Ref
2100574
Required Education
Bachelors Degree
Position Type
Full time
Intern- Analytical Operations, Core Team
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company’s five core values. That’s because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible


Dissolution testing is an integral part of drug product (DP) development in which an appropriate method is essential to monitor the DP batch-to-batch dissolution consistency and/or ideally to predict the in vivo release of active pharmaceutical ingredient (API). However, the dissolution profile of each DP is unique, depending on the formulation and solubility of the API. As a result, developing an appropriate dissolution method for DP development purpose is not always straightforward, e.g. understanding the solubility rate in each dissolution medium, how much surfactant is appropriate, what type of surfactant to use, etc. This research proposal is intended to study/predict the dissolution profiles of various DPs from the perspective of contact angle and surface tension of dissolution media at the solid/liquid interface of common excipient blend and respective drug loading of BCS Class II and IV API. These studies will in turn help to elucidate the relationship between wettability, media surface tension and dissolution. The intern will work under direct supervision of experienced analytical chemists performing research and development analyses. Training will include basic hands-on introduction to quantitative sample preparation, dissolution with analysis by ultra-violet spectrophotometer, and surface tension and contact angle measurement using a tensiometer.

Responsibilities

The analyst will understand the wetting properties of a surfactant with a drug surface to establish the relation between wettability and dissolution of drug product. The analyst will be responsible for preparation of reagents and materials to execute experiments. Under the guidance of an experienced chemist, the intern will measure contact angle and surface tension using a tensiometer, perform dissolution testing and analyze samples using ultra-violet spectrophotometer. The analyst will organize these results into concise research summaries and provide a final presentation documenting the outcome of the research studies.

Experie nce

Completion of at least 1-year of chemistry education in a bachelor's degree program, including laboratory courses. Completion of coursework in analytical chemistry is desired to provide a background in operating principles of the analytical tools used.

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

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