Scientist, Genome Editing Immunology

South San Francisco, South CA, South United States
Nov 27, 2020
Biotech Bay
Required Education
Position Type
Full time

Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14 and CasPhi, Mammoth Biosciences provides enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Mammoth is democratizing disease detection with easy and affordable point-of-care tests that allow real-time and simultaneous detection of multiple conditions, along with high-throughput tests that allow for unprecedented testing volume. Further, the company is transforming disease treatment with its proprietary micro-sized CRISPR proteins that enable new editing and delivery options. Based in San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX, and 8VC, and leading individual investors including Brook Byers, Tim Cook, Bob Nelsen, and Jeff Huber. At Mammoth, we are passionate about transforming lives through innovation.


We are seeking an outstanding and driven Scientist to join our team. The successful candidate will possess deep knowledge and a strong publication record on Immunology, Immuno-oncology and/or cancer immunotherapy. You will be providing scientific and technical expertise establishing in vitro assays and in vivo models and generating proof of concept data and developing candidate therapeutics. The successful candidate will have excellent organizational and communication skills and thrive in a collaborative and fast-paced team environment.

    • Utilize strong background in immunology to support existing programs and develop new concepts, methods and in vitro and in vivo models to advance broader discovery and therapeutic efforts.
    • Cellular engineering and cell therapy manufacturing including viral transduction and non-viral genome editing
    • Communicate key scientific data to project teams and senior management with clear interpretation of data and proposal of next steps

    • PhD or MD
    • Post-doctoral research experience with demonstrated expertise in one or more of the following areas: cellular and molecular immunology, immuno-oncology, innate immunity, T/B cell biology, cancer immunotherapy, and/or related field
    • A strong publication record in peer-reviewed journals
    • Demonstrated expertise in isolation, characterization, and genetic manipulation of primary immune cells (T cells, NK cells)
    • Strong expertise in a wide range of cellular immunological assays for functional characterization of immune cells, including advanced multi-parameter flow cytometry (8+ colors), T cell activation, proliferation, phenotyping, antigen processing, cell killing, cytokine secretion, immunogenicity and cytotoxicity assays
    • Familiarity with in-vivo mouse models of tumor immunotherapy, GvHD and/or immune-related toxicity
    • Proficiency with molecular biology, cloning, PCR, genome editing, transfections, and retroviral/lentiviral/AAV viral vector engineering and production

    • Experience in the biotechnology or pharmaceutical industry is preferred
    • Previous experience with gene therapy, manipulation and multi-lineage differentiation of hHSCs or iPSCs is a plus
    • Excellent organizational skills with high degree of professional integrity and strong work ethic, be team-oriented
    • Strong interpersonal and communication skills

    • Competitive salary with equity
    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Free breakfast/lunch/dinner/barista
    • Free gym
    • Public transportation commuter subsidy
    • 401(k) matching