Senior Scientist I, Analytical Chemistry

South San Francisco, CA, United States
Nov 25, 2020
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments.

This position is based at AbbVie in Redwood City, CA, which is an R&D organization focused on development of innovative biologics in the field of Oncology.


The Senior Scientist I, Analytical Chemistry will report into the Protein Analytical Chemistry Department within the CMC Biologics organization in Redwood City, CA. The Protein Analytical Chemistry Department is responsible for all aspects of CMC analytical development required to move biologic candidates from discovery into and through clinical studies.

In this lab based role, you will utilize your knowledge of protein chemistry and expertise in chromatography and capillary electrophoresis to contribute to development of AbbVie's growing pipeline of clinical stage oncology biotherapeutics, which include novel bispecific constructs, antibody-drug conjugates, and monoclonal antibodies. You will characterize and investigate attributes of biologic drug candidates to provide product and process understanding, as well as develop innovative analytical methods that provide deeper insights into protein biotherapeutics across the development spectrum from candidate liability screening to process development to clinical development.

Key Responsibilities Include:
  • Independently develop state of the art capillary electrophoresis and HPLC methods to characterize biotherapeutic proteins and their associated variants and impurities.
  • Characterize post-translational modifications and structure-activity relationships of products under development.
  • Develop innovative approaches to solve difficult analytical challenges.
  • Represent the Protein Analytical Chemistry Department as a subject matter expert on cross functional project teams.
  • Develop, qualify/validate, and transfer fit-for-purpose QC release and stability methods.
  • Provide technical support and oversight for QC testing occurring at internal and external GMP laboratories.
  • Plan and author characterization, comparability, and quality sections of regulatory submissions (INDs/CTDs).
  • Engage and influence the broader scientific community through publications and poster and oral presentations at industry conferences.


  • BS/MS with a minimum of 10+ years of relevant experience and strong industry track record of scientific accomplishment or Ph.D. in Chemistry, Biochemistry, or related field with a minimum of 0-3 years of relevant experience.
  • Must possess a solid understanding of protein chemistry and biochemistry, particularly as it relates to biotherapeutic protein drug development.
  • Demonstrated proficiency in developing and performing capillary electrophoresis and HPLC methods as they apply to protein characterization.
  • Experience with CMC analytical development of monoclonal antibodies or related biotherapeutic proteins is preferred, but not required.
  • Proven record of advanced technical/scientific achievement and innovation.
  • Quality control and/or GMP experience is beneficial.
  • Must have strong written and verbal communications skills.
  • Must be capable of working in a fast-paced, collaborative environment and managing multiple concurrent projects with a high degree of independence.

Significant Work Activities
Awkward/forceful/repetitive motions (arms above shoulders, bent wrists, etc.)
Yes, 5 % of the Time
Job Type
Job Level Code
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.