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Research Associate II - Huang Lab

Employer
Gladstone Institutes
Location
San Francisco, CA, United States
Start date
Nov 25, 2020

View more

Discipline
Science/R&D, Research, Laboratory
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay

Job Details

Category:
Science
Lab/Area:

Huang Lab

Description:

Gladstone's Center for Translational Advancement (GCTA) seeks aResearch Associate II/IIIin human iPSC culture and stem cell technique to help develop and take charge of the large-scale stem cell culture, differentiation, and maintenance pipeline for our large-scale drug re-positioning effort. This candidate will have the opportunity to shape and take ownership of a critical component of the new center's drug re-purposing infrastructure.
  • Develop and maintain the pipeline for consistent production of multiple iPSC-derived cell types at scale.
  • Responsible for the culture, maintenance, propagation, and differentiation of the cell lines.
  • Differentiation of human iPSC lines into neural and glial cell types, using consensus protocols.
  • Provide regular quality assurance reports detailing culture quality, consistency, and cleanliness.
  • Provide training to incoming researchers where necessary.
  • Exercise resourcefulness, creativity and proactivity to seek out answers to unforeseen difficulties or problems outside range of expertise.
  • Implement operational modifications where necessary to improve accuracy, efficiency, and cost-effectiveness
Qualifications
  • BS or MS in a field of BiologicalSciences required.
  • 2+ years' experience in a laboratory setting applying human stem cell culture techniques.
  • Must be skilled in pluripotent human stem cell culture, propagation and differentiation, with excellent aseptic technique.
  • Large-scale drug screening experience preferred.
  • Exceptional organizational and documentation skills.
  • Previous experience starting a lab or building a cell-culture program would be ideal.


The ideal candidate will be personally motivated to accelerate the development of underutilized compounds into treatments for under-treated diseases. S/he will thrive in an environment of team science, where many minds rally around a common goal, in a culture of support and collaboration. The objective of the person in this position will be to build and run a robust, large-scale pipeline for consistent production of multiple brain cell types from human iPSCs, for screening with FDA-approved compounds, with the goal of re-purposing those compounds for new treatments for neurological and neurodegenerative diseases.

About the Gladstone Center for Translational Advancement

The Gladstone Center for Translational Advancement (GCTA) was created in 2017 to find unforeseen uses for existing drugs. Seeking new uses for FDA-approved drugs, which have already passed safety tests, can help bring treatments to patients more quickly. This "drug re-purposing" approach drastically lowers the cost and shortens the timeline of drug development.

Headed by Senior InvestigatorYadong Huang, MD, PhD, the center provides crucial resources to develop re-purposed drugs that target diseases of the central nervous system, the heart, and the immune system. The center aims to accelerate the conversion of basic research findings into efficient clinical candidates and, ultimately, medical applications.

The center includes three major components:
  • Build a drug repositioning database of up to 15,000 compounds using human cells derived from induced pluripotent stem cells (iPSCs). The database will outline how each drug affects healthy and diseased human genes.
  • Establish infrastructure to test repurposed drugs in cell culture and animal models for potency, pharmacokinetic (PK), and pharmacodynamic (PD) studies in collaboration with Gladstone Senior Investigator Sheng Ding and the School of Pharmaceutical Sciences at the Tsinghua University in Beijing.
  • Promote human clinical trials of re-purposed drugs, in collaboration with medical centers and pharmaceutical companies in the US and abroad.

Additional Information:

  • Title and salary will be commensurate with education and experience.
  • Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health.
  • Gladstone is an equal opportunity employer.

Company

Gladstone is an independent, nonprofit life science research organization located in the epicenter of biomedical and technological innovation in the San Francisco Bay Area. Gladstone has created a research model that disrupts how science is done, funds big ideas, and attracts the brightest minds. Gladstone Institutes leads the way for innovative research in the biomedical field. We always seek dedicated and talented individuals to join our team.

Scientists know that using a diversity of approaches is often the most efficient strategy for solving a problem. New and different perspectives engender the very innovation that Gladstone prizes. This is one of the many reasons why we value diversity at Gladstone—be that a diversity of race, culture, religion, mental or physical ability, heritage, age, gender, sexual orientation or other characteristics. Our employees hail from more than 30 countries around the globe and we seek to hire the best and brightest for our diverse team of scientists and administrators. Career opportunities are available in both our administrative offices and our research areas.

Our Benefits
Gladstone offers eligible employees—and their dependents—a comprehensive range of benefits, including health insurance, retirement savings, and professional development.

Highlights

  • Health and Retirement
    • A choice of medical plans, flexible spending account, and retirement account options that include employer contributions help you take care of your health and your future.
  • Time Away from Work
    • More than just vacation days, our paid and unpaid leave policies offer flexibility to help you confront different stages of life including maternity and paternity leave, as well as other types of family leave.
  • Professional Development
    • Gladstone encourages employees to seek the skills they need to remain at the forefront of their profession. By supporting professional development workshops and continuing education, Gladstone provides employees with the resources they need to evolve in their role and in their career.
  • Gladstone Cares
    • A specially selected suite of benefits to support you in and out of the workplace. Includes resources for dealing with the many stages of life to specific coverage for family planning, and back-up child or elder care coverage.
Company info
Website
Location
1650 Owens Street
San Francisco
California
94158
United States

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