Investigator I (Formulation & Delivery / Nanoparticle)

Employer
CSL Behring
Location
Cambridge, Massachusetts
Posted
Nov 24, 2020
Ref
R-125591
Required Education
Doctorate/PHD/MD
Position Type
Full time
About CSL

With operations in 35+ nations and ~27,000 employees worldwide, CSL is driven to develop and deliver a broad range of lifesaving therapies to treat disorders such as hemophilia and primary immune deficiencies, and vaccines to prevent influenza. Our therapies are also used in cardiac surgery, organ transplantation and burn treatment.

CSL is the parent company of CSL Behring and Seqirus. CSL Behring is a global leader in the protein biotherapeutics industry, focused on bringing to market biotherapies used to treat serious and often rare conditions. CSL Behring operates CSL Plasma, one of the world's largest collectors of human plasma, which is used to create CSL's therapies. Seqirus is one of the largest influenza vaccine companies in the world and is a transcontinental partner in pandemic preparedness and a major contributor to the prevention and control of influenza globally.

We invite you to take a look at the many career possibilities available around the globe and consider building your promising future at CSL by becoming a member of our team!

Job Description

Job Summary:

This Investigator is a responsible for development and performance of mRNA vaccine and adjuvanted protein vaccine formulation and delivery technology, to support vaccine discovery and development.

Major Responsibilities:

mRNA vaccine formulation and delivery development
  • Development of delivery technology eg. Lipid nanoparticle, for efficient and safe delivery of mRNA vaccine.
  • Development of mRNA vaccine formulation to improve vaccine stability.


Vaccine formulation to support vaccine development
  • Development and performance of mRNA vaccine formulation, biophysical characterization and stability evaluation to support vaccine process development.
  • Performance of mRNA vaccine and adjuvanted protein vaccine formulation to support vaccine preclinical development in animal models.


Documentation and presentation of scientific results
  • Write experimental protocols and prepare internal reports. Maintain lab notebooks.
  • Present research project progress within and beyond Research.
  • Lead technical advancements and publications.
  • Interact with cross-functional project teams and stakeholders as key contact.
  • Interact with external collaborators as key contact.


Lab management
  • Maintain functional laboratory equipment and follow HSE regulation.


Minimum Requirements:
  • Ph.D. in Pharmaceutical Science, Chemistry, Biomedical engineering, Biochemistry or a related field
  • 0-3 year academic or pharmaceutical/biotech experience in biologics formulation and delivery
  • Strong knowledge and experience with nanoparticle fabrication and characterization is required.
  • Strong knowledge and experience with medicinal chemistry especially lipid chemistry is required.
  • Knowledge and experience with mRNA molecular biology and biochemistry are desired.
  • Creative and the ability to generate accurate and reproducible results along with multi-tasking and working effectively in a fast-paced environment are critical.
  • Strong organizational, written and oral communication skills and ability to work in teams is essential.