Sr. Scientist, Process Chemistry
- Employer
- MyoKardia, Inc (acquired by BMS)
- Location
- Brisbane, California, United States
- Start date
- Nov 23, 2020
View more
- Discipline
- Engineering, Manufacturing & Production, Process, Science/R&D, Biotechnology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Bay
Job Details
The Senior Scientist will join our process chemistry team within Manufacturing and Technical Operations and take a key role in route scouting, process optimization and process development of API. An ideal candidate is someone with a strong understanding of modern organic chemistry, has a track record of creative design and problem solving, and a broad synthetic organic background. He/she will be responsible for executing in-house process chemistry efforts at MyoKardia as well as supporting the process development and GMP manufacturing efforts of API at contract manufacturing organizations (CMOs). He/she will also work closely with Medicinal Chemistry and Analytical Development to design and develop more efficient synthetic routes to facilitate API manufacturing for all programs at MyoKardia. The ideal candidate is highly creative, energetic, team focused and thrives in an intellectually rewarding collaborative and science driven environment.
Essential duties and responsibilities include but are not limited to the following:
- Execute in-house route scouting, process development and optimization studies to facilitate scale up and transfer to CMOs
- Evaluate synthetic routes and test alternatives that facilitate scale up of both target compounds and building blocks
- Plan and synthesize multi-step organic syntheses intermediates and products; maintain detailed documentation of experimental procedures and results
- Assist to resolve API manufacturing issues through effective problem solving
- Maintain and troubleshooting all equipment in process chemistry lab
- Collaborate with CROs/CMOs to source appropriate starting materials, intermediates, drug substance, and other materials as needed
- Provide technical support to CROs/CMOs for technical transfer
- Keep abreast of all relevant publications and guidance documents
Position Requirements and Experience:
- A demonstrated track record of delivering results with high integrity, quality focus and collaboration
- A Ph.D. in Organic Chemistry, with at least 5 years (M.S. with 8 years or B.S. with 10 years) of relevant experience in the biotech/pharmaceutical industry
- Strong Laboratory bench skills including synthesis, purification and analysis of organic compounds using HPLC (UV and MS detection), NMR, IR, GC, TLC and elemental analysis.
- Expert knowledge of synthetic organic chemistry, process chemistry, modern analytical methods and physical-chemical characterization of compounds
- Experience with performing organic reactions under inert/dry atmosphere, moisture sensitive chemicals environment
- Proven ability to work in a high paced manufacturing team environment to meet on time product delivery deadlines and a track record of creative design and problem solving.
- Demonstrated ability to develop, optimize and scale up drug substance manufacturing processes in multistep organic synthesis
- Experience with chemical process optimization or process development is a plus.
- Excellent oral and written communications skills
- Excellent organizational skills, with ability to successfully manage multiple priorities
- Ability to work effectively with cross-functional teams
- Highly self-motivated and detail-oriented, with proven ability to work independently
Company
MyoKardia’s mission is to change the world for people with serious cardiovascular disease through bold and innovative science. MyoKardia is a clinical-stage bio pharmaceutical company discovering and developing targeted therapies for the treatment of serious cardiovascular diseases. The company is pioneering a precision medicine approach to its discovery and development efforts by 1) understanding the bio mechanical underpinnings of disease; 2) targeting the proteins that modulate a given condition; 3) identifying patient populations with shared disease characteristics; and 4) applying learnings from research and clinical studies to inform and guide pipeline growth and product advancement. MyoKardia’s initial focus is on small molecule therapeutics aimed at the proteins of the heart that modulate cardiac muscle contraction to address diseases driven by excessive contraction, impaired relaxation, or insufficient contraction. Among its discoveries are three clinical-stage therapeutics: mavacamten (formerly MYK-461); danicamtiv (formerly MYK-491) and MYK-224. Founded in September 2012 MyoKardia is headquartered in Brisbane, CA.
- Website
- http://www.myokardia.com/
- Phone
- 650-741-0900
- Location
-
1000 Sierra Point Parkway
Brisbane, CA 94005
US
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