Scientist II-III, Neurobiology

Durham, NC, United States
Nov 23, 2020
Bio NC
Required Education
Position Type
Full time
Precision BioSciences is searching for a highly collaborative cell/molecular biologist with expertise in neurobiology (alt: neuromuscular biology; neuroscience) to join our Therapeutic Discovery team based in Durham, NC. The team is expanding its therapeutic portfolio with the development of treatments for specific neurological disorders using Precisions proprietary ARCUS gene editing platform. The ideal candidate for this Scientist position should have a strong background in the pre-clinical in vitro and in vivo biology that covers neurodegenerative and neuromuscular diseases. The successful candidate will join a team charged with the design, execution and analysis of experiments to advance gene-editing programs. The Scientist II/III should also be current in the pertinent literature and possess excellent communication and interpersonal skills that enable effective communication with project teams.

Essential Duties and Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.
  • Design and implementation of cell-based models and assays (mammalian cell lines, primary cell culture, induced pluripotent stem cells (iPSCs) etc.) for the molecular screening and functional characterization of ARCUS nucleases
  • Design in vivo experiments to validate ARCUS nucleases for gene editing programs, including processing tissues for histology and analysis by microscopy.
  • Develop and run PCR-based assays (qPCR, RT-qPCR, ddPCR, etc.) with high sensitivity and reproducibility
  • Support the development and optimization of ARCUS nuclease delivery platforms (e.g., AAV, lipid nanoparticles (LNPs), etc.)
  • Identify and engage, as required, external CROs for molecular biology support, plasmid/viral vector production and bioanalytical assays for animal studies
  • Responsible and accountable for the execution of experiments and coordination with CROs to perform analytical and bioassays on test materials for projects.
  • Present experimental designs and results to various audiences at project meetings and department meetings
  • Maintain organized and detailed electronic records to support internal documentation needs and regulatory submissions
  • Ability to multitask and contribute to multiple projects under demanding timelines

In order to perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
  • PhD in cellular & molecular biology/neuroscience with 2-5+ years related academic or industry experience and/or training
  • Experience with management of projects in a matrixed organizational structure and/or management of small research teams is a plus
  • Preference given to candidates with in-depth knowledge and experience with cell culture and cell-based assays involving neuronal cells, satellite cells, iPSCs and relevant end points, including proliferation, cytotoxicity, and differentiation markers
  • Experience with animal models of neurodegenerative and/or neuromuscular diseases is preferred
  • Experience and knowledge of molecular biology techniques is desired, including: PCR, restriction digestion & cloning, primer design, plasmid isolation and analysis, bacterial transformation and screening, extraction of genomic DNA, DNA sequencing and analysis, and proficiency with accompanying data analysis software
  • Familiarity and experience with protein engineering, gene editing, AAV biology a plus.
  • Ability to read, analyze, and interpret common scientific journals. Ability to define problems, collect and analyze data, establish facts, and draw valid conclusions. Should have knowledge of Microsoft Office software suite
  • Ability to respond to common inquiries or complaints from customers, regulatory agencies, or members of the business community
  • Ability to apply advanced mathematical concepts such as exponents, logarithms, quadratic equations, and permutations
  • Ability to apply mathematical operations to such tasks as frequency distribution, determination of test reliability and validity, analysis

  • This is an office-based position located at the main headquarters in downtown Durham, NC

  • This position involves little to no travel

Precision BioSciences is dedicated to improving life through its proprietary genome editing platform, ARCUS. Precision BioSciences leverages ARCUS in the development of its product candidates which are designed to treat human diseases and create healthy and sustainable food and agriculture solutions. Precision BioSciences is actively developing product candidates in three innovative areas: allogeneic CAR T immunotherapy, in vivo gene correction, and food.

Precision BioSciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.