Executive Director, Mechanistic disease biology and combinations, Oncology

Foster City, CA, United States
Nov 22, 2020
Required Education
Position Type
Full time
Executive Director, Mechanistic disease biology and combinations, Oncology
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

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Inclusion is one of the company’s five core values. That’s because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

Executive Director, Mechanistic disease biology and combinations, Oncology

We are seeking a highly motivated and experienced individual with drug development and diagnostics expertise at the executive director level. This individual will lead mechanistic disease biology and combination (MDB) analyses within Research Biology. The role will be responsible for characterizing disease and therapeutic mechanism of action, developing and delivering on strategies that identify rationale-based molecular combinations and target indications for Gilead's oncology pipeline and clinical stage molecules.

The successful candidate will work within cross-functional teams to deliver data packages pairing mechanism-based analyses of drug and disease to match patients with the most appropriate therapeutic. This position will oversee the integration of these mechanistic analyses with clinical development. The executive director will be accountable for discovering and developing patient enrichment strategies, ensuring translation to practical applications in the clinical setting. The scope of responsibilities spans design, experimental execution, data analysis and interpretation to inform assays for initial patient selection and stratification strategies. The successful candidate will bring deep scientific experience with in-depth knowledge of oncology and clinical development perspective, and expertise in matrix-based management. The executive director will be a strong team player who thrives in a cross-functional environment and elevates the performance of their colleagues.

Responsibilities: Leads the MDB team and drives activities related to identification of rationale-based combinations and practical patient selection criteria for Gilead's clinical stage and oncology pipeline molecules.

Designs and drives implementation of strategy to interrogate disease pathobiology combined with mechanistic analyses of therapeutics.

Cultivates innovative thinking, working with teams across research, bioinformatics functions and other relevant functions to identify areas of novel opportunity.

Establishes strong internal collaborative teamwork and represents the MDB function on cross-functional project teams, including early and late stage development, to ensure alignment of objectives across the drug development continuum

Drives the generation of a strong KOL collaborative network and identifies key collaborations to complement Gilead's internal research efforts.

Represents the MDB function in collaborations with other industry partners and projects.

Drives the generation of high quality presentations and publications for internal and external audiences. Contributes to clinical study protocols, clinical study reports and Medical Affairs publications as appropriate.

Represents the MDB function and makes clear presentations, or leads colleagues through presentations, to senior management and project review as appropriate.

Develops and mentors a MDB team of innovative and highly motivated team players to impact Gilead's oncology drug development pipeline.

Qualifications and Experience:

Experienced PhD / MD/ MD PhD scientist with 15+ years of relevant industry experience in oncology and immuno-oncology drug development.

Deep understanding of the role of mechanistic and pathobiological analyses in drug development, and strong working knowledge of all functional areas of drug development, including research, clinical development and diagnostic development.

Ability to place practical considerations in context with research data and to make rational, risk:benefit balanced decisions in ambiguity / with incomplete information when necessary.

Experience with in vitro and in vivo cancer models, and integrating PK/PD/efficacy information

Experience working with primary human samples, including pre- and post-analytical considerations. Demonstrated experience in the appropriate application of various scientific technologies to research strategies.

Experience leading teams through hypothesis-based interrogation of multi-parametric data sets including proteomics and genomics.

Track record of excellence establishing productive collaborations with KOLs and academic institutions. Experience with business development is preferred.

A team player mindset is essential, with the ability to navigate cross-functional teams to produce results in line with Gilead's innovative objectives.

Excellent verbal and written communication skills across all levels both within an organization and with external collaborators.

Demonstrated ability to build and develop a highly functional, motivated and integrated research team.

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

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