Scientist II, Cell and Molecular Biology

About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

General Position Summary/Purposes:
The Scientist II will be a key member of the Research Biology team responsible for providing strong technical expertise and implementation to support drug discovery and novel target identification and validation in hematologic malignancies. The candidate will be responsible for executing tasks to achieve departmental and project goals. The candidate should be proficient in standard molecular biology, cell culture and biochemistry techniques and is expected to clearly communicate the scientific rationale, methodology and results in written and oral formats.

Key Accountabilities/Core Job Responsibilities:

• Demonstrate scientific knowledge and independence to establish and implement strategies for exploring the mechanisms of action of novel molecules to support translation into future therapies for new indications in hematological malignancies.
• Hands-on execution: Advance science from the bench, design and execute various biochemical and cellular assays to determine potency and selectivity of small molecules to understand their SAR and mechanism of action.
• Work with supervisors to improve assay protocols and take the leading role in the development, optimization, and validation of new assays. Utilize technical expertise and available information to troubleshoot and resolve key assay hurdles when encountered.
• Apply basic cell and molecular biology techniques to identify and evaluate cellular efficacy and selectivity endpoints.
• Perform tasks with diligent attention to detail and high level of accuracy. Prioritize tasks and contribute to a highly motivated and productive research team with a sense of urgency and desire to meet project timelines.
• Accurately document, critically analyze/interpret data and communicate the results promptly
• Strong interpersonal skills to thrive in a team environment

Qualifications

• BS with 7 or more years of relevant laboratory experience or MS with 5 or more years of relevant laboratory experience required with training in cancer biology. Experience working on hematologic cancers is highly desired.
• Demonstrated ability to design, execute and interpret experiments via publications, external presentations or patents
• Effective written and verbal English communication skills

Experience:

• Experience in cell culture (suspension and adherent) and latest molecular and cellular biology assays including but not limited to DNA/RNA/protein purification, lentiviral transduction, CRISPR, RNAi, immunoprecipitation, WES, ELISA, MSD, qPCR, and colorimetric assays
• Expertise in multi-color immunophenotyping, flow cytometry and cell imaging techniques
• Experience with cell-based assay development, optimization and troubleshooting
• Experience in establishing and fully validating compound potency assays using cell lines or primary human cells is essential. Experience in using cell biology models to elucidate molecular mechanisms of action
• Basic knowledge on biological data analysis tools (GraphPad Prism, FACS DIVA software, FlowJo, Image Studio, Compass) and computer applications such as MS Word, MS Excel and MS PowerPoint.
• Contribute to lab and equipment maintenance and help create a safe, effective and efficient working environment.

Significant Work Activities
Awkward/forceful/repetitive motions (arms above shoulders, bent wrists, etc.)
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.