Amgen

Postdoctoral Fellow- Biologics Optimization: CHO Cell Engineering for Targeted Integration

Employer
Amgen
Location
Thousand Oaks, CA, US
Posted
Nov 21, 2020
Ref
R-92952
Required Education
Bachelors Degree
Position Type
Full time
The Amgen Postdoctoral Program is committed to providing future scientists with an enriched environment to encourage innovation that will contribute to the generation of human therapeutics.

We have an exciting new opening for a postdoctoral researcher in the Mammalian Expression group within Biologics Optimization at Amgen. The focus of this role is to generate novel mammalian expression systems utilizing state-of-the art genome editing and vectorology approaches. The goals are to enhance protein and vector variant library screening technologies by generating genome edited targeted integration CHO hosts and vectors; and, to improve the productivity and quality of difficult to express proteins such as bispecifics. This work may impact patients through the development of next generation biologics optimization screening approaches and novel manufacturing systems.

The successful applicant will perform independent research within the context of a highly collaborative environment and with access to state-of-the-art technologies and resources, including molecular biology, mammalian expression, protein purification and analytics, and genomics. This fellowship will provide scientific training, the opportunity to publish, and exposure to the industrial biotechnology environment at Amgen.

The assignment length is expected to be 3 years long.

Basic Qualifications
  • PhD. or Doctorate degree to be completed by March, 2020.
Preferred Qualifications
  • PhD in Molecular Biology, Cell Biology, Genomics, or Biochemistry.
  • Proven expertise and publications using current gene-editing technologies, including CRISPR/Cas9 mediated genome engineering, as applied to mammalian and CHO systems.
  • Experience in the generation and utilization of CHO targeted integration expression systems.
  • Proficiencies in plasmid cloning, mammalian cell culturing, and genomics technologies.
  • Record of independent critical thinking and the ability to design, execute, and interpret experiments, as exemplified by high quality peer-reviewed publications.
  • Research expertise in genomics data analysis.


Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.