Amgen

Principal Scientist - Biotransformation

Employer
Amgen
Location
South San Francisco, CA, US
Posted
Nov 20, 2020
Ref
R-89780
Required Education
Bachelors Degree
Position Type
Full time
Amgen is seeking a highly motivated scientist to join the Pharmacokinetics & Drug Metabolism (PKDM) department at our site in South San Francisco, California. Amgen provides a collaborative and creative culture in a company with a strong track record of innovation. Our culture encourages open dialogue and diverse views to land on the best solutions, and we help ensure our staff are equipped to excel today and tomorrow.

The department of pharmacokinetics and drug metabolism (PKDM) within Amgen is dedicated to the discovery and development of novel effective, safe medicines. The successful candidate will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

Position Responsibilities

The Bio-transformation Principle Scientist leader will be in charge of implementing cutting edge separations and mass spectrometry tools (LC/MS) for the identification, quantitative and qualitative analysis of novel drug candidates and their metabolites from in vitro and in vivo biological matrices. The role will provide opportunity to work with broad range of scientific expertise and leadership across the Research organization. The role will broadly cover biotransformation of small molecules, proteins and RNAi therapeutics.

The ideal candidate will have a proven ability to design and execute experiments to conduct metabolite identification, isolation and characterization, have general understanding of enzyme kinetics, and understand clearance mechanism in support of both drug discovery and development programs. This role requires an excellent understanding of preclinical in vivo models, in vitro ADME and bioanalytical techniques. This role is ideally suited for an individual that can work collaboratively in a fast-paced work environment. The candidate should also assist in new technology, strategies, and data processing implementation. Other responsibilities/opportunities will include writing scientific reports, author original scientific manuscripts and present results to project teams or at scientific meetings.

Basic Qualifications

Doctorate degree and 3 years of Scientific experience
OR
Master's degree and 6 years of Scientific experience
OR
Bachelor's degree and 8 years of Scientific experience

Preferred Qualifications
  • PhD or MS in chemistry, biochemistry, or equivalent.
  • Experience with operation, troubleshooting, and data interpretation of a mass spectrometer is required.
  • Experience with operation of automated liquid sample handling instruments and experience with analysis of radiolabeled compounds is desired.
  • The candidate should possess excellent oral and written communication skills and be able to excel in a highly collaborative, matrixed team environment.
  • Interactions and collaboration with academic and other external scientists are encouraged.


At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our "people-first" philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

Consistent with our core leadership value of "Develops the Best Team," we are seeking leaders that prioritize the development of talent. As a manager, your first priority and primary role is to accelerate the performance and development of your team. We expect managers to exemplify strong leadership and champion self-awareness and career development Ways that you will display your leadership acumen in this role include:
  • Mentoring, coaching, and developing staff to build highly-skilled, diverse, and inclusive teams
  • Fostering a positive and respectful work environment that encourages staff retention and motivates individuals to work toward common goals and priorities
  • Ensuring that staff understand how their efforts and contributions make a meaningful impact to the business
  • Growing core skills and capabilities among staff, particularly in learning agility, problem solving, strategic and creative thinking, flexibility, resilience, effective communication, prioritization, delivery of results, and continuous improvement
  • Making accurate evaluations of your team's skills and competencies and providing timely and respectful feedback, including direct delivery of difficult messages
  • Developing an understanding of your team's career objectives and serve as a thought-partner in their career development plans
  • Assisting staff with preparing for roles of growing responsibility and identifying new opportunities that expand their skills and align with their overall career objectives
  • Resolving critical gaps in the organization's internal capabilities and skill sets, including strategic external recruiting
  • Identifying diverse, qualified successors for key positions
  • Ensuring that direct reports who also lead people consistently demonstrate these same behaviors with their staff


Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.