Senior Scientist, CAR-T Immuno-oncology

Cambridge, MA, United States
Nov 19, 2020
Required Education
Masters Degree/MBA
Position Type
Full time
Our mission:

Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Intellia Therapeutics, a CRISPR/Cas9 company, is seeking a CAR-T cell scientist to lead the functional characterization of our allogeneic CAR-T cell products. This talented and highly motivated Senior Scientist will join our Immuno-oncology group. In this lab-based role you will develop and functionally characterize CAR-T cell drug products for our ex vivo portfolio. Prior IO cell therapy experience is highly desired as you will lead key aspects of in vitro and in vivo CAR-T development at Intellia. The successful candidate will be comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities. Intellia is a cross-functional team first organization, as such experience working well in teams in an industry setting is key.

    • MS or PhD in Immunology, Cell Biology, or related field with typically 8+ (MS), or 5+ (PhD) years of relevant experience
    • Strong expertise in human T cell biology and in vitro functional assays utilizing human primary T cells; experience with CAR T, TCR-T, or a related cell therapy platform to target hematologic and/or solid tumors is required
    • Hands-on experience with in vitro and ex vivo phenotypic and functional assays of primary human immune cells, including multicolor flow cytometry, cytotoxicity / cytokine assays, MLR, and cell tracking in vivo is highly desired
    • Hands-on proficiency in primary immune cell isolation and culture
    • Experience working with cell-line derived, PDX, or GEM murine tumor models

    • CAR T cell generation, functional assessment and immunophenotyping
    • Coordinate and collaborate with colleagues to execute in vivo studies to assess CAR-T cell anti-tumor efficacy and safety using mouse models
    • Work collaboratively with other biologists and protein engineers
    • Creative thinking to propose and implement innovative cell engineering approaches to expand company's preclinical pipeline and intellectual property
    • Maintain detailed records of experimental protocols and results
    • Stay up to date on the latest scientific and technology advancements in the field
    • Position will involve supervision and guidance of other scientists
    • Work productively in a team environment and independently to deliver against timelines.


What Intellia Stands For:

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.

- Explore because we seek new ways to tackle disease. Explore with unbounded from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.

- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Intellia's web-based application process is managed through Lever. Information submitted through application forms is collected by Lever and subject to Lever's privacy policy .