Associate Scientist II/Scientist I, In-Vivo Pharmacology

South San Francisco, CA, United States
Nov 19, 2020
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .


Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of noveloncology therapies. More than 1,000 AbbVie scientists, statisticians, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at AbbVie's South San Francisco oncology site.

We are looking for an Associate Scientist II/Scientist I with experience in in vivo pharmacology study execution in various mouse models of cancer. The main role will involve conducting in vivo research studies from start to finish including tumor implantation, data collection, and data analyses. Additional opportunities to learn new skills and to work on ex vivo lab experiments will be provided as smaller roles, and based on project need and candidate's interest. Above all, we are looking for a highly motivated and collaborative individual with a passion for oncology research, who enjoys working in a fast-paced and highly dynamic working environment.

  • Execute, monitor, and interpret in vivo studies involving CDX, PDX, disseminated and syngeneic models, etc. for various cancer subtypes
  • Evaluate novel cancer therapeutics in vivo through studies such as efficacy, PK, and tolerability
  • Independently lead aspects of projects or workflows
  • Collect and process tissue/blood samples
  • Prepare compound formulations and dose animals
  • Analyze and report data regularly at team meetings
  • Potential to undertake cell culture for implanting in in vivo studies


Associate Scientist II:
  • Bachelor's Degree, or equivalent education with 3+ years of experience or Master's Degree or equivalent education with 0+ years of experience.

Scientist I:
  • Bachelor's Degree or equivalent education with 5+ years of experience, or Master's Degree or equivalent education with 2+ years of experience.

For both levels:
  • Strong technical expertise in in vivo experimentation, including health monitoring, tumor implantation, tumor measurements, dosing via IP, IV, SC, PO routes, and blood/tissue collection
  • Experience with mouse models of cancer, including CDX (cell line derived) and/or PDX (patient derived) xenograft models preferred
  • AALAS certification is preferred but not required
  • Excellent laboratory, record keeping, data analysis, and critical thinking skills
  • Experience with cell culture is a plus but not required
  • A team player with excellent verbal and written communication skills
  • Strong organizational skills, attention to detail, and time-management skills enabling efficiency and independence
  • Willingness to have schedule flexibility and to split weekend and holiday hours with peers on a rotational basis

Significant Work Activities
Awkward/forceful/repetitive motions (arms above shoulders, bent wrists, etc.)
Yes, 5 % of the Time
Job Type
Job Level Code
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.