Translational Scientist

San Francisco, CA, United States
Nov 18, 2020
Biotech Bay
Required Education
Position Type
Full time
Who you are

We are seeking a highly motivated biomarker scientist to support the discovery and development of biomarkers for therapeutic programs across the BridgeBio subsidiaries of mendelian genetic diseases and genetically-defined cancers.

The biomarker scientist will work with other scientists within BridgeBio as well as contract research organizations to identify, design, implement, and validate candidate biomarker assays for multiple disorders relevant to BridgeBio's subsidiary companies. The ideal candidate will have a proven track record of experimental science either directly in or relevant to the development of biomarker assays and/or companion diagnostics. This position reports to the director of translational science.

Key skills for this role include reading and understanding published biomarker approaches, rapidly learning new therapeutic and disease areas, interfacing and collaborating with internal scientists, CRO teams, and cross-functional teams who are experts on a particular disease program. Hands on experience with experimental science and assay development is a must.

  • Develop biomarker and target engagement assays to support research and development decisions and clinical trials
  • Work independently and collaboratively with scientists at BridgeBio subsidiaries, consultants, and CROs in support of biomarker development, assessment, qualification and validation
  • Rotate focus among multiple BridgeBio subsidiaries over time to provide biomarker expertise, strategy and support
  • Draft biomarker or surrogate endpoint sections of regulatory submissions

Education, Experience & Skills Requirements:
  • Ph.D., MD/Ph.D. or equivalent experience in pharmacology, biochemistry, or related discipline
  • 2+ years biotech industry experience in assay and biomarker development
  • Experience developing and implementing biomarker assays using various modalities (qPCR, ELISA, IHC, Western blot, flow cytometry)
  • Experience drafting regulatory submission documents
  • Experience evaluating novel technology approaches including platform and instrument assessment
  • Ability to coordinately analyze diverse data sets including bioinformatics where appropriate
  • Ability to work in a small company with a largely virtual environment
  • Ability to manage complexity and uncertainty
  • Strong team interaction and communication skills
  • Embraces the BridgeBio core values: 1. put patients first; 2. think independently, 3. be radically transparent; 4. every minute counts; and 5. let science speak

What We Offer:
  • Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
  • A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
  • Learning and development training to help employees be the best version of themselves
  • Collaborative business environment
  • Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
  • Excellent benefits package
  • Flexible PTO
  • With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
  • A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
  • Work with the most productive groups of R&D operators in the industry
  • Partnerships with leading institutions
  • A platform for meaningful scientific contributions to shine
  • Commitment to Diversity & Inclusion - with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so