Lead Scientist, Organic/Medicinal Chemistry

Ambrx, Inc.
La Jolla, CA
Nov 17, 2020
Biotech Beach
Required Education
Position Type
Full time

Lead Scientist, Organic/Medicinal Chemistry

(Job: 20-20BR)


About Ambrx:

Ambrx Inc., is a clinical-stage biopharmaceutical company focused on developing Precision Biologics using an expanded genetic code. Ambrx technology uses an expanded genetic code to incorporate synthetic amino acids into protein, all completed within a living cell. These synthetic amino acids enable the creation of Precision Biologics, an exciting new class of therapeutics with broad application and potential. This includes next-generation antibody drug conjugates (ADCs), bispecifics, and targeted immuno-oncology therapies for cancer as well as smart cytokines to modulate the immune system, and long-acting therapeutic peptides for metabolic and cardiovascular disease.

We are seeking a highly creative and motivated organic/medicinal chemist with project leadership skills to be a key member of dynamic research organization. The successful candidate will be part of a growing chemistry team who can contribute to discovering novel protein therapeutics to help patients in need.


Primary Responsibilities:

  • The successful candidate will lead internal/external programs and cross-functional teams to execute project plans
  • Lead our small molecule, linker, peptide design strategies and synthesis
  • Independently carryout structure-activity relationship studies and interpret experimental results to propose new compound designs
  • Proven ability to initiate new programs and understanding of biology concepts to deliver proof-of-concept data to make Go/No Go decisions
  • Proven ability to identify problems and propose solutions to move programs forward
  • Carryout analytical and preparative method development to support internal chemistry needs
  • Communicate research findings to the key stake holders and present in project meetings/conferences
  • Contribute to patent application writing and research reports
  • Identify and establish working relationships with CROs and manage external chemistry resources
  • Safe keeping and operation of lab and lab equipment


  • Ph.D. in organic/medicinal chemistry or related field with minimum 8-12 years of industry experience as a Chemist
  • Must have experience working with antibody drug conjugates (ADCs) and understanding of ADC field
  • Proven track record in drug discovery project leadership and demonstrated success in Hit/Lead identification and optimization and carrying out SAR studies
  • Experience in structure-based and pharmacophore-based drug designs
  • Experience in modern synthetic organic chemistry techniques, designing new synthetic routes for biologically active molecules and carrying out multi-step synthesis in milligram to multi-gram scale
  • Hands-on experience with analytical and purification equipment HPLC, LC-MS and NMR etc.
  • Must have excellent presentation, written and verbal communication, organization, and collaborative skills



To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code. Applicants whose qualifications and experience most closely match the requirements of the position will be reviewed. Candidates will only be contacted for evaluative discussions. Ambrx offers competitive compensation & benefits.

Job: 20-20BR