Scientist, Mammalian Cell Culture Process Development

Employer
Ambrx, Inc.
Location
La Jolla, CA, United States
Posted
Nov 15, 2020
Ref
24-20BA
Hotbed
Biotech Beach
Required Education
Doctorate/PHD/MD
Position Type
Full time
Ambrx is a clinical-stage biopharmaceutical company enabling a new field of protein medicinal chemistry, using a technology that directs the incorporation of amino acids beyond nature's conserved set into biosynthetic proteins to produce high value biological products such as antibody-drug conjugates. Ambrx is seeking a highly motivated scientist to be a key member of a fast-paced and dynamic organization.

Primary Responsibilities:

This position will focus on upstream process development and lead the efforts for developing and
optimizing the cell culture process including medium development, feeding strategies, process
parameter optimization, process characterization and scale-up for large scale production to support
R&D, pre-clinical, and clinical activities. This individual will design and carry out experiments and provide
technical leadership and serve as the subject matter expert on project teams and work closely with
other groups to provide support for the Company's projects. The candidate will monitor, explore and
evaluate next generation technologies to speed up process development. This individual will also be
involved with technology transfer to third parties including partners and CMO.

Qualifications:
• Ph.D with 0-4 yrs industry experience in Biochemical Engineering, Chemical Engineering, Biochemistry or related field
• Hands-on experience with CHO or other mammalian cells for mAb or recombinant protein production is a must.
• Hands-on experience using spin tubes, shake flasks, and bioreactors is desired
• Previous experience in cell culture scale-up, tech transfer including drafting development reports, production batch records, protocols and knowledge of scale-up and scale-down models is highly desired
• Knowledge of statistical design of experiments in process development and optimization
• Previous experience in cell culture media development and cell culture platform development is a plus
• Ability to succeed in a multidisciplinary, fast changing, and diverse team environment
• Clear and solid verbal communication skills
To be considered as an applicant, please submit your resume/CV referencing the specific position of
interest and position code to careers@ambrx.com. Applicants whose qualifications and experience most
closely match the requirements of the position will be reviewed. Candidates will only be contacted for
evaluative discussions. Ambrx offers competitive compensation & benefits. EOE