Senior Process Engineer, LNP Process Sciences

Location
Cambridge, MA, United States
Posted
Nov 15, 2020
Ref
1765392609
Hotbed
Genetown
Required Education
Bachelors Degree
Position Type
Full time
Our mission:

Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Intellia is seeking a highly skilled and motivated Sr. Process Engineer to join our LNP Process Sciences team. The successful applicant will have a strong background in scale-up, process development, and manufacture of particle-based drug products. The candidate will focus on developing and implementing scalable and robust processes related to the formulation of lipid nanoparticles (LNP) with nucleic acids. In addition, the role will help lead late-stage drug product development activities for lead pre-clinical programs through process robustness/characterization studies, understanding product quality, and helping to refine the product control strategy. The successful candidate must be able to work in a fast paced and highly dynamic environment.

Responsibilities:
    • Design and execute experiments related to process improvements and optimization of lead Lipid Nanoparticle formulations
    • Lock the process and define critical process parameters.
    • Lead experiments to confirm robust process performance
    • Explore, develop, and scale-up novel drug product processes
    • Characterization of final nanoparticle formulations in conjunction with Analytical Development
    • Interact with internal and external groups to manufacture and supply formulations for in vivo studies
    • Prepare technical reports and presentations as it relates to process optimization and scale-up
    • Write and review protocols and batch records for drug product processes
    • Develop intellectual property, publishing scientific papers and other tasks related to the company's scientific and business interests


Qualifications:
    • BS in Life Sciences, Chemical or Biological Engineering with 10+ years of industry experience, or Masters with 7+ years of industry experience
    • Experience designing, executing, and analyzing particle-based drug delivery systems
    • Demonstrated experience with process development and scale-up of complex drug products
    • Preferably has prior experience with LNP formulations with nucleic acids
    • Preferably has prior experience working with a frozen or lyophilized particle-based drug product.
    • Demonstrates creativity and problem-solving skills
    • Ability to work independently, as well as part of a team
    • Organized, detail-oriented, and a self-starter who continuously seeks to improve existing laboratory methods and processes.
    • Effective verbal and written communication skills.


#LI-KO1

What Intellia Stands For:

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.

- Explore because we seek new ways to tackle disease. Explore with unbounded minds...free from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.

- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Intellia's web-based application process is managed through Lever. Information submitted through application forms is collected by Lever and subject to Lever's privacy policy .