Senior Scientist I, Chemistry

South San Francisco, CA, United States
Nov 15, 2020
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .


AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. AbbVie is also expanding their expertise through partnering with companies leading the way in emerging biologic technologies including oncolytic virus' and CAR-T cells. This position is based at AbbVie in the South San Francisco/or Sunnyvale location.

The successful candidate will participate in discovery synthetic chemistry efforts aimed at identifying and developing novel linker/payload technologies for preclinical evaluation and clinical use.

  • The successful candidate will have strong synthetic skills, outstanding attention to detail and excellent record keeping abilities.
  • Synthesize, purify and characterize biologically active organic small molecules and linkers through multi-step synthesis.
  • Contribute to optimization and validation of synthetic routes applicable for synthesis of linker-drugs on multigram scale.
  • Maintain excellent experimental records for research and development efforts.
  • Contribute to development and optimization of analytical characterization methods.
  • Proactively seek out new information in the literature and incorporate into individual projects.
  • Effective writer and communicator of research or other regulatory materials.



Senior Scientist I:
BS or MS in synthetic organic chemistry and typically 10 years of experience (BS) or 8 years of experience (MS), or PhD and typically 0-4 years of experience.
  • Demonstrated competency and experience in multistep organic synthesis
  • Strong small molecule purification skills
  • Knowledge of common spectroscopic and analytical techniques (NMR, LCMS, HPLC)
  • Highly organized and disciplined record keeping
  • Strong attention to detail
  • Strong verbal and written communication skills are essential
  • Excellent laboratory practices and safety techniques are essential
  • Ability to multitask and meet deadlines in a fast-paced environment

Significant Work Activities
Awkward/forceful/repetitive motions (arms above shoulders, bent wrists, etc.)
Yes, 5 % of the Time
Job Type
Job Level Code
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.