Senior Research Associate, Analytical Development - Mol Bio

Location
San Diego, CA, US
Posted
Nov 15, 2020
Ref
5553
Hotbed
Biotech Beach
Required Education
Associate Degree
Position Type
Full time
Overview

Ready to join a team committed to developing and commercializing gene therapies for patients and families devastated by rare neurological genetic diseases? Since 2013, Novartis Gene Therapies (formerly AveXis) has had one focus: bringing change to those devastated by genetic diseases.

The Novartis Gene Therapies culture embraces this mission. As a compassionate and dedicated team, we are enthusiastic about the science behind our work and finding answers to difficult questions. We are dedicated to communities affected by rare diseases, and these patients and families are the motivation for everything we do.

We have built a team with exceptional depth of experience, unified by a common vision; to develop gene therapies with the potential to positively impact the lives of the patients and families devastated by rare and life-threatening neurological genetic diseases. Though we are proud of what we have achieved to date, we remain relentlessly focused on making that vision a reality.

The Senior Research Associate, Analytical Development - MolBio, performs routine testing and to establish analytical methods suitable for lot disposition and characterization of gene therapy drug products and substances.

Responsibilities
  • Performs a wide variety of laboratory tasks and experiments independently. May lead training of junior team member. Support design, develop and troubleshoot assays, chemistry and methods.
  • Independently operates laboratory equipment such as thermocyclers, spectrophotometers, fluorometers, centrifuges, cell counters, scales, capillary electrophoresis instrumentation, sequencers, ddPCR, real-time PCR platforms and DNA isolation workstations. May lead training of junior members.
  • May be the POC on maintains laboratory equipment and inventory levels for laboratory supplies; order lab supplies, chemical reagents, properly document sample receiving. May lead training of junior member.
  • Uses laboratory techniques such as preparation of buffers and media, aseptic technique, cell culture, sample processing, PCR, gel and capillary electrophoresis and sequencing independently, and may lead training of junior member.
  • Maintains a laboratory notebook that records all aspects of experimental design and results, following good documentation practices. When applicable, maintains electronic copies of experiments, procedures, instructions, data and analysis in appropriate locations.
  • Develop, optimize and qualify a section of analytical methods suitable for gene therapy characterization, lot release and stability monitoring, may participate in assay transfer to QC department under minimal supervision. May lead one subproject of method development and write report with supervision. May be the author of SOPs/WI, Forms for developed methods.
  • Performs routine sample testing and data analysis with existing analytical methods in support of regulatory filings and manufacturing process development and validation.
  • Performs data analysis using one of available software such as Microsoft Excel, JMP and R scripts with minimal supervision.
  • Ensures laboratory reagents are properly documented, stocked, dated, and that laboratory bench space is clean and clutter-free.
  • Other related job duties as assigned.

Qualifications
  • Bachelor's degree in Biology, Biochemistry, Bioengineering or related scientific discipline with 4 years research experience in area or 7 years of equivalent education/experience may be accepted.
  • 4 years of industry experience in a regulated environment; GMP, NGS experience highly advantageous.
  • Quick learner, highly motivated, hard-working and detail oriented. Strong ability to work in a fast-paced team environment with highly goal-oriented approaches and to prioritize work from multiple projects with can-do attitude is required.
  • Ability to follow and adhere to Standardized Operating Procedures (SOPs) as well as written and verbal instructions.
  • Developed technical writing skills, able to create and deliver small presentations before groups of professionals under minimal supervision.


The level of this position will be based on the final candidate's qualifications.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

Novartis Gene Therapies is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.