Senior Research Scientist, Structural Chemistry

Senior Research Scientist, Structural Chemistry
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company’s five core values. That’s because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible


As a member of the Modeling Group you will work closely within inter-disciplinary project teams deployed in multiple therapeutic areas. In this critical role you will be responsible for proactively delivering structural and computational expertise to influence efforts in target and lead identification as well as lead optimization.

Essential Functions:

Responsible for directing and executing scientific research for the discovery and development of drug candidates or the research support of marketed drugs. Investigates the feasibility of applying advanced principles and techniques of related scientific specialty to potential inventions, products and problems. Recommends the development of economical, state-of-the art techniques toward the discovery of therapeutic products. Plans, designs, implements and analyses computational strategies to advance scientific knowledge of drug substances or techniques to identify such substances. Provides direction to research associates or members of project teams in the initiation and execution of laboratory experimentation, considering economic and safety factors. Works on complex problems where analysis of situations or data requires evaluation of intangible variables, requiring regular use of ingenuity and creativity. Makes contributions to scientific literature and conferences through publication and presentation of research results. Participates in development of patent applications. Acts as a resource and provides work direction for other research personnel.

Knowledge, Experience & Skills:

Essential:

Typically requires a PhD in an appropriate scientific discipline and 5+ years of relevant experience that demonstrates an expertise in a specific field and sustained excellence in performance and accomplishments that align to company goals. Excellent communication skills (both verbal and technical) and interpersonal skills are required. Must be able to participate in highly effective teams. Exercises independent judgment in developing methods, techniques and evaluation criteria for obtaining results. Demonstrates ability to recognize anomalous and inconsistent results and interpret experimental outcomes. Maintains in-depth knowledge of state-of-the art principles and theories, applying such knowledge to the research direction that supports Company interests. Demonstrates technical proficiency, scientific creativity, collaboration with others and independent thought in suggesting experimental design and research strategy. Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.

Experience in a broad variety of computational techniques is essential, particularly molecular docking, pharmacophore development, library design and analysis, machine learning methods, and protein-ligand simulation. The ability to analyse chemical structures in relation to biological activity to guide novel compound design or help evolve the SAR, both independently and in collaboration with medicinal chemists, is crucial.

Solid knowledge of medicinal chemistry principles, including DMPK, as well as the understanding of IP and its analysis is expected. Excellent communication skills along with the ability to function as an effective member on multiple project teams are mandatory. The ability to develop tools for computational and medicinal chemistry would be a great plus.

Desirable:

Proficiency with the Schrodinger Software Suite and an aptitude toward creating tools and workflows with Pipeline Pilot will be very useful.

For jobs in the United States:
As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the ‘EEO is the Law' poster.

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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:
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