AbbVie

Senior Scientist I

Employer
AbbVie
Location
Worcester, MA, United States
Posted
Nov 14, 2020
Ref
2008472
Required Education
Masters Degree/MBA
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

AbbVie is embracing new paradigms and technologies to develop novel and life-changing therapies for cancer. We are seeking a highly motivated and energetic teammate to operate in a LC/MS-based quantitative bioanalytical role to support research and development projects.

The LC/MS bioanalytical team is looking for an experienced Bioanalytical Sr. Scientist to lead qualitative and quantitative bioanalysis of large molecules to support drug discovery and early development projects at AbbVie. The ideal candidate will be highly skilled in the optimization and implementation of novel bioanalytical methods to drive in-vivo PK, TK, and PK/PD as well as in-vitro stability characterization of large molecules. Have experience in analyzing and interpreting bioanalytical data and effectively communicate to the project teams.

Key tasks and responsibilities:
  • Expert in developing qualitative and quantitative assays for biotherapeutics characterization using LCMS .
  • Optimize and implement bioanalytical methods for identifying and quantifying antibody and antibody drug conjugates, proteins, peptides, and small molecules using LC-MS/MS.
  • Expert in developing quantitative assays for protein biomarkers, targets, and different biologics modalities.
  • Serve as a subject matter expert in immunoaffinity capture LCMS using automation for biologics stability evaluations.
  • Continuously improve bioanalytical workflows efficiency and ensure laboratory capacity meets project demand. Writes and maintains Protocol and facilitate assay optimization and implementation to ensure data quality.
  • Mentor junior analysts with bioanalytical assays on small and large molecules, especially antibody drug conjugates.

Qualifications

Education and Experience:
  • Degree in chemistry, biochemistry, pharmacology or other related field. PhD with 3+ years or MS with 6+ years of experience in a pharmaceutical industry setting.
  • Highly motivated individual with a strong intellectual and technical background in preclinical DMPK and bioanalytical methods, specifically large molecule LC-MS/MS. Expertise in qualitative LC-MS analysis of large molecules.
  • Deep and broad knowledge in analytical science and applied technologies. Direct hands-on experience and strong trouble shooting skills in LC/MS bioanalytical laboratory (High end QTOF MS, Triple quad MS, and automation).
  • Knowledge in drug discovery and related disciplines. In-depth understanding of in-vitro assays as well as in vivo PK, tox studies and corresponding bioanalytical assays. Demonstrated ability to manage and analyze data using advanced software tools.
  • Excellent verbal and written communications skills and ability to excel in a team environment. Strong analytical, organizational and communication skills. Work in team environment, and mentor group of analysts.
  • Desire to excel in a fast-paced environment.

Significant Work Activities
N/A
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.