Scientist II/ Senior Scientist I, Proteostasis

Cambridge, MA, United States
Nov 14, 2020
Required Education
Position Type
Full time
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Job Description:

AbbVie has invested in a new research enterprise in Cambridge, Massachusetts - the Cambridge Research Center (CRC). As part of CRC, the AbbVie Foundational Neuroscience Center (FNC) is investigating the fundamental biological mechanisms underpinning neurodegenerative diseases with particular attention to Alzheimer's disease (AD) and Parkinson's disease (PD). Multiple studies implicate proteostasis pathways as potential therapeutic targets for AD and PD. Our discovery research team aims to understand how these proteostasis pathways may be therapeutically modulated to improve clinical outcomes in these diseases.

We are seeking a highly motivated cell/molecular biologist, preferably with pharma/biotech background, to join the Proteostasis group at the FNC. This individual will make substantial contributions to the team's early drug discovery efforts to identify and validate novel drug targets. The candidates should have extensive laboratory research experience and a desire to continue in a laboratory-focused role. Strong communication and teamwork skills are essential as this individual is expected to operate in a fast-pace multi-disciplinary environment. This individual should enjoy working with novel technologies and thrive in a small biotech atmosphere with the resources of a large pharmaceutical company. Additional responsibilities include assay development and validation, as well as characterization of model systems to study proteostasis biology and its contribution to neurodegenerative disease.

Key Responsibilities:
  • Maintain a high level of productivity in the laboratory, and contribute technical and scientific expertise to proteostasis project teams
  • Identify and validate new drug targets
  • Independently design, execute, and interpret critical experiments to answer scientific questions
  • Generate robust and complete data sets to support key Go/NoGo decisions on novel drug targets
  • Develop expertise with novel technologies and laboratory techniques
  • Lead and/or assist in writing and revising SOPs
  • Work diligently and efficiently to meet deadlines in a fast-paced environment
  • Read and apply relevant scientific literature
  • Adhere to safety and compliance
  • Participate and present in internal meetings
  • Publish research in peer-reviewed journals and present work at scientific forums


  • PhD or MS or BA in Molecular Biology, Cell Biology, Neuroscience or related field with 7-10+ years (BA), 5-8+ years (MS), or 0-4 years (PhD) of pharmaceutical/biotech industry/academia experience
  • Strong background and expertise in proteostasis pathways (e.g., the ubiquitin-proteasome system) and/or neurodegeneration are preferred
  • Experience working with primary rodent neurons and/or iPSC-derived neurons is required
  • Strong scientific writing skills, excellent verbal communication skills, and ability to work well in a collaborative team-oriented environment
  • Proficiency with cell culture techniques, transfection, and viral transduction methods
  • Proficiency with cellular analytical techniques such as immunofluorescence microscopy, high-content imaging, and flow cytometry.
  • Demonstrated ability to learn, understand and master new experimental techniques
  • Strong organizational skills that enable multitasking and working within timelines

Significant Work Activities
Yes, 5 % of the Time
Job Type
Job Level Code
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.