Scientist, Delivery Science (Formulation / Analytical Development)

Location
Cambridge, MA, United States
Posted
Nov 13, 2020
Ref
2130269334
Hotbed
Genetown
Required Education
Masters Degree/MBA
Position Type
Full time
Our mission:

Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.

Intellia is seeking a highly skilled and motivated Scientist to join our team. The primary responsibilities for this position will be to design and develop lipid nanoparticles, execute routine and advanced characterization, for developing mechanistic insights related to lipid nanoparticle (LNP) mediated RNA delivery. The candidate will be responsible to optimize existing analytical methods, develop new analytical assays and formulation processes, generate standard operating procedures (SOPs) and test method documents. As a part of routine work the candidate will plan and conduct experiments, independently and in collaboration with colleagues to support project goals, acquire and analyze respective data to inform decision making, trouble-shoot experiments and instrumentation to reach desired goals. The candidate will communicate research and development findings with internal and external partners; operate and maintain multiple laboratory instruments; assist in maintaining general laboratory functionality, including lab equipment maintenance, ordering, and receiving of lab supplies.

GENERAL RESPONSIBILITIES:
    • Formulation and characterization of LNP and nanoparticle delivery systems
    • Characterize LNPs using advanced characterization techniques (UPLC, LC-MS, DLS, etc.)
    • Extensive experience with UPLC/HPLC-based analytics and experience developing and running routine assays and novel assay development
    • Experience in characterizing and developing novel drug delivery systems for nucleic acids, proteins, or small molecules
    • Able to develop and implement SOPs for novel analytical methods
    • Experience with preparation of nanoparticle-based formulations at different scales sufficient to support in vitro and in vivo studies (rodents).
    • Leverage findings to drive rational design of next gen delivery platform
    • Conduct experiments, independently and in collaboration with colleagues in support of project goals
    • Design, implement, troubleshoot and modify experiments to reach desired goals
    • Communicate research and development findings with internal and external partners
    • Operate and maintain multiple laboratory instruments
    • Assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering and receiving of lab supplies


SKILLS:
    • Strong understanding of nanoparticle-mediated delivery (current challenges and barriers to efficacy particularly in vivo ) and previous experience with formulation and characterization.
    • Analytical experience with chromatography is a must additional experience with Mass spectrometry is a plus.
    • Broad skillset that enables communication across multiple disciplines (biology, chemistry, materials, physics, etc.)


QUALIFICATIONS:
    • PhD in Engineering, Chemistry, Materials or Pharmaceutical Sciences with 0-2 years of industry experience OR M.S. in Engineering, Chemistry, Materials or Pharmaceutical Sciences with 5-7 years of relevant industry experience
    • A strong background in nanoparticle characterization / material characterization/ chromatography / spectroscopy / drug development is highly desired


#LI-DG1

What Intellia Stands For:

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us - trusting and counting on every single one of us.

- Explore because we seek new ways to tackle disease. Explore with unbounded minds...free from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

- Disrupt by thinking courageously...and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts...with that breed of skepticism that shows you have better solutions.

- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards...even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Intellia's web-based application process is managed through Lever. Information submitted through application forms is collected by Lever and subject to Lever's privacy policy .