Principal Scientist Group Leader - Immunology

Location
Seattle
Posted
Nov 13, 2020
Ref
4961178002
Hotbed
BioForest
Required Education
Doctorate/PHD/MD
Position Type
Full time
JOB PURPOSE

Sana Biotechnology is looking to expand our team with hard-working individuals who believe in the potential of cells as engineered medicines, have the vision to do creative things, and the determination to execute that vision. Works on projects of diverse scope. Exercises judgement within broadly defined practices to select methods, techniques and evaluation criteria. Demonstrated success in technical proficiency, scientific creativity, collaboration and independent thought.

Sana has a research opportunity in Immunology to positively impact projects in the pipeline that are pioneering a transformative new approach to engineering cells as medicine. This scientist will develop and execute the scientific strategy for novel platforms to enhance efficacy of T cell therapies across multiple disease indications, as well as provide immunology expertise across cell and gene therapy within Sana.

DUTIES AND RESPONSIBILITIES
  • Lead and mentor a group of PhD and non-PhD level scientists in the development and implementation of in vitro assays and in vivo animal models to understand and optimize Sana platforms and identify optimal lead CAR-T candidates
  • Apply deep expertise in T cell immunology to design and execute an experimental strategy focused on optimizing platform T cell therapies to maximize efficacy and understand mechanisms of action
  • Evaluate new technologies and animal models for T cell functional characterization to increase experimental efficiencies and confidence in lead identification
  • Collaborate closely with in vivo pharmacology, gene therapy and vector development teams to coordinate resources, manage program timelines and ensure high quality delivery
  • Manage the preparation of data packages for presentations to internal stakeholders and external parties and author and prepare manuscripts for publication
  • Contribute to the design and execution of IND-enabling studies and preparation of associated non-clinical study reports
  • Contribute to a dynamic, exciting culture that embraces teamwork and innovation

QUALIFICATIONS

Required Qualifications
  • Ph.D. in Immunology or similar discipline with 8+ years of post-Ph.D. in academia or industry
  • Consistent record of cutting-edge research and becoming an emerging leader in T cell immunology
  • Experienced people manager and leader of cross-functional discovery teams
  • Deep/ knowledge of T cell immunology with insight into T cell effector function, including T cell differentiation, T cell exhaustion and persistence, and stimulatory/inhibitory regulatory mechanisms
  • Technical expertise in T cell immunotherapy and/or transplant animal models, including immune deficient/humanized and syngeneic murine models
  • Strong working understanding of tumor cell biology, tumor microenvironment and strategies to overcome mechanisms of immune evasion
  • Technical expertise in assays to characterize human and mouse T cell phenotype and function, including cytotoxicity, proliferation, cytokine production, chemotaxis, multiparameter immunophenotyping (flow and mass cytometry) and NGS analyses
  • Must be highly effective collaborator with strong written/verbal communication and interpersonal skills
  • Strong desire to translate novel cell and gene therapies into effective medicines for the treatment of cancer