Research Associate / Sr. Research Associate - Pre-Clinical Research

Employer
Nkarta Inc
Location
South San Francisco, CA, United States
Posted
Nov 12, 2020
Ref
31184
Hotbed
Biotech Bay
Required Education
Associate Degree
Position Type
Full time
Research Associate / Sr. Research Associate - Pre-Clinical Research

Founded at the birthplace of biotechnology, Nkarta's mission is to discover, develop and deliver novel off-the-shelf (e.g. allogeneic) natural killer (NK) cell therapies that profoundly impact patients' outcomes and survival . The company is based on the proprietary, robust and well-characterized NK cell expansion technology pioneered by Dr. Dario Campana. Nkarta is focused on leveraging the inherent power of NK cells to identify and kill abnormal cells and recruit adaptive immune effectors to generate responses that are deep and durable.

Nkarta combines its NK cell expansion and cryopreservation platform with proprietary cell engineering technologies to generate an abundant supply of NK cells, engineer enhanced NK cell recognition of tumor targets, and improve persistence for sustained activity in the body for the treatment of cancer.

Founded in 2015, Nkarta became a public company (Nasdaq symbol NKTX) in 2020. Our development pipeline of engineered NK cell therapy candidates consists of two co-lead programs, NKX101 and NKX019. The IND for NKX101 for the treatment of relapsed or refractory AML and higher-risk MDS was accepted by the FDA in July 2020. We expect to begin dosing patients in this study by the end of 2020. As we broaden the development of NKX101, we also plan to initiate studies in solid tumors. Our second co-lead program, NKX019, is designed to target B cell lymphomas. We plan to file our IND for NKX019 with the FDA in early 2021. In addition, we recently completed the construction of a GMP compliant clinical manufacturing facility in our South San Francisco location designed to produce viral vector and supply our initial clinical trials.

Position Title Research Associate / Sr. Research Associate

Location South San Francisco, CA

Reports to Senior Scientist, Pharmacology

Position Summary

This role adds to our growing pre-clinical team to support the development of Nkarta's NK cell therapy pipeline.

Key Responsibilities
  • • Conducts pharmacological evaluation of test agents (cell products or small molecules) in subcutaneous, systemic and orthotopic in vivo oncology models.
  • Supports flow cytometry or PCR analysis of sample and subsequent data analysis to profile test agents in vivo activity
  • Contributes to preclinical research through development or validation of new tumor models.
  • Performs research and/or development independently or in collaboration with other scientists.
  • Ensures compliance with good laboratory practices and other regulatory guidelines.
  • Understands and implements study protocol according to AAALAC and other guidelines.

Key Responsibilities
  • Conducts pharmacological evaluation of test agents (cell products or small molecules) in subcutaneous, systemic and orthotopic in vivo oncology models.
  • Supports flow cytometry or PCR analysis of sample and subsequent data analysis to profile test agents in vivo activity
  • Contributes to preclinical research through development or validation of new tumor models.
  • Performs research and/or development independently or in collaboration with other scientists.
  • Ensures compliance with good laboratory practices and other regulatory guidelines.
  • Understands and implements study protocol according to AAALAC and other guidelines.


Education / Experience

B.Sc. in the Biological Sciences or closely related field with a minimum of 3 years of experience or M.Sc. with 1 years of experience, preferably within the Pharmaceutical/Biotechnology sector.

Working Environment

This position requires the ability to occasionally lift and/or move up to 25 pounds. Specific vision abilities for this job include close vision, depth perception, and ability to adjust focus. The common requirements of an office environment (computers, computer screens, workstations, etc.) apply when not working in or around the laboratory environment.

About Nkarta

The 80+ team members at our South San Francisco, California headquartered location describe working at Nkarta, along with opportunities for improvement, in some of the following ways:

  • "Work is interesting - lots of projects in the pipeline (so I don't have to worry about the one project failing). Leadership is open, straight forward."
  • "Smart, capable, nice people. People I work with day to day are enjoyable."
  • "Employee-centric."
  • "I like that the company is open minded with a (people) -(looking for) a set of skills that can grow (as opposed to thinking you have to have exactly what's in a job spec now) Things that broaden their (employees) skills and growth."
  • "Like any startup there are fires to put out; feel confident we have the people to control those fires."
  • "Diverse people from different backgrounds."
  • • "I like that the company is open minded with a (people) -(looking for) a set of skills that can grow (as opposed to thinking you have to have exactly what's in a job spec now) Things that broaden their (employees) skills and growth."
  • • "Like any startup there are fires to put out; feel confident we have the people to control those fires."
  • • "Diverse people from different backgrounds."


To learn more about our work at Nkarta and the career opportunities that will drive us forward to serve patients, please visit the company's website at https://www.nkartatx.com