Rigel is looking for a highly motivated and productive hands-on PhD scientist just starting out on a pharmaceutical career to join the medicinal chemistry group. The successful candidate will be innovative, team-oriented, working with transparency and integrity to take early stage small molecule hits, turn them into a lead candidates and ultimately a clinical candidate. The research group provides an ideal environment in which to see the process of drug discovery, to be an integral member of the chemistry group as well as to see and be involved in the biology and pharmacokinetic aspects of the project.
The successful applicant will be part of a dynamic chemistry group that is able to adapt rapidly to new project priorities and has a genuine curiosity for science. One needs to be comfortable with techniques in synthetic organic chemistry – executing reactions, isolating and analyzing products – with the ability to communicate the results of the laboratory to both chemistry and the research group more generally.
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Develops novel and efficient synthesis, coordinates research strategies and activities with team members and conducts the synthesis of complex target molecules
- Will be expected to work as part of a multi-disciplinary team towards the project goals
- Designs synthetic targets for lead discovery and optimization to address issues of target potency, selectivity, pharmacokinetics, and in vivo efficacy
- Utilizes contemporary structure-based methods, structure-activity relationships, and medicinal chemistry principles to propose and execute innovative chemistry strategies
- Uses literature and database searches to design and execute synthetic routes to chemical targets
- Maintains a current understanding chemical literature – synthesis, medicinal chemistry and methodology, as well as general scientific curiosity
- Keeps an accurate, comprehensible and concise notebook
- Represents own research to chemistry group and research more generally
KNOWLEDGE AND SKILL REQUIREMENTS:
- Ph.D. in Organic Chemistry or Medicinal Chemistry with sound laboratory skills laboratory experience
- 0-5 years’ post-doctoral experience
- A record of accomplishment in design and execution of multi-step target molecules
- Clear general knowledge of chemistry and a diverse practical experience in synthetic organic chemistry and a zeal for problem solving
- Broad understanding of experimental design and reaction mechanisms
- High level of professional expertise in modern laboratory and analytical methods
- Demonstrated independent thought/creativity in science and possesses a high degree of scientific discretion/intuition
- Ability to articulate laboratory results (both oral and written) in a concise but comprehensive manner to the chemistry group and more broadly to the Research team as a whole
- Proficient with Chemistry specific software (ChemDraw, Word, Excel, Scientific database searching, ChemBl)
- Possesses scientific and cultural curiosity
- Ability to present oneself with a level of comportment expected of a professional
- PHYSICAL DEMANDS: While performing the duties of this job, the employee is required to stand, walk; sit; talk and hear. Specific vision abilities required by this job include close vision, distance vision, peripheral vision, depth perception and the ability to adjust focus.
- WORK ENVIRONMENT: The noise level in the work environment is usually moderate. Some travel may be required.
Rigel Pharmaceuticals, Inc. is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by the law.